Human HLA-G Recombinant Protein (RPPB3692)

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SKU:
RPPB3692
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
HLA-G
Synonyms:
Major Histocompatibility Complex
Synonyms:
Class I
Synonyms:
G
Synonyms:
HLA-G Histocompatibility Antigen
Source:
Escherichia Coli
Uniprot:
P17693
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Description

Product Name:Human HLA-G Recombinant Protein
Product Code:RPPB3692
Size:10µg
Species:Human
Target:HLA-G
Synonyms:Major Histocompatibility Complex, Class I, G, HLA-G Histocompatibility Antigen, Class I, G, MHC Class I Antigen G, B2 Microglobulin, HLA G Antigen, HLA Class I Histocompatibility Antigen, Alpha Chain G, Mutant MHC Class Ib Antigen, Mutant MHC Class I Antigen, MHC Class Ib Antigen, HLA-6.0, MHC-G, HLAG, HLA class I histocompatibility antigen, alpha chain G, HLA G antigen, MHC class I antigen G.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:HLA-G protein solution (0.25mg/ml) contains 20% glycerol and PBS (pH 7.4).
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMGSHSM RYFSAAVSRP GRGEPRFIAM GYVDDTQFVR FDSDSACPRM EPRAPWVEQE GPEYWEEETR NTKAHAQTDR MNLQTLRGYY NQSEASSHTL QWMIGCDLGS DGRLLRGYEQ YAYDGKDYLA LNEDLRSWTA ADTAAQISKR KCEAANVAEQ RRAYLEGTCV EWLHRYLENG KEMLQRADPP KTHVTHHPVF DYEATLRCWA LGFYPAEIIL TWQRDGEDQT QDVELVETRP AGDGTFQKWA AVVVPSGEEQ RYTCHVQHEG LPEPLMLRWK QSSLPTIPI

HLA-G (Major Histocompatibility Complex Class I G) is a member of the HLA class I heavy chain paralogues. This class I molecule is a heterodimer which comprises a heavy chain as well as a light chain, beta-2 microglobulin, while the heavy chain is fixed in the membrane. HLA-G is expressed on fetal derived placental cells. HLA-G is a non-classical class-I HLA molecule linked with immuno-modulatory & anti-inflammatory properties which interacts with inhibitory receptors such as, ILT2/ILT4/KIR2DL4, that are present on different immune cells. HLA-G inhibits the proliferation of T cells, B cells & natural killer cells, moreover it also induces regulatory T cells.

HLA-G Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 309 amino acids (25-308 a.a) and having a molecular mass of 35.3kDa.HLA-G is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

NCBI Summary:HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
UniProt Code:P17693
NCBI GenInfo Identifier:122132
NCBI Gene ID:3135
NCBI Accession:P17693.1
UniProt Related Accession:P17693
Molecular Weight:Predicted Molecular Mass: 36.4kDaAccurate Molecular Mass: 38kDa as determined by SDS-PAGE reducing conditions.
NCBI Full Name:HLA class I histocompatibility antigen, alpha chain G
NCBI Synonym Full Names:major histocompatibility complex, class I, G
NCBI Official Symbol:HLA-G  
NCBI Official Synonym Symbols:MHC-G  
NCBI Protein Information:HLA class I histocompatibility antigen, alpha chain G
UniProt Protein Name:HLA class I histocompatibility antigen, alpha chain G
UniProt Synonym Protein Names:HLA G antigen; MHC class I antigen G
UniProt Gene Name:HLA-G  
UniProt Entry Name:HLAG_HUMAN
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