The Human HLA-DR Monoclonal Antibody (PE-Cyanine7 Conjugated, L243, AGEL1396) offered by AssayGenie is a powerful tool designed for research involving human immune responses. This monoclonal antibody specifically targets the HLA-DR protein, a major histocompatibility complex class II molecule involved in antigen presentation to T cells.With high reactivity in human samples, this antibody is essential for detecting and analyzing HLA-DR expression in various cell types. Its PE-Cyanine7 conjugation allows for multi-color flow cytometry, enabling precise and efficient identification of HLA-DR-positive cells.
HLA-DR is a crucial player in the immune system, mediating immune responses by presenting antigens to T-helper cells and initiating adaptive immune responses. Understanding the role of HLA-DR is vital in research areas such as immunology, infectious diseases, and transplantation.By using the Human HLA-DR Monoclonal Antibody (PE-Cyanine7 Conjugated, L243, AGEL1396), researchers can gain insights into the immune system's functions and dysregulation, paving the way for advancements in areas like vaccine development, autoimmune diseases, and transplant rejection mechanisms.
Product Title:
PE/Cyanine7 Anti-Human HLA-DR Antibody [L243]
SKU:
AGEL1396
Size:
20 Tests, 100 Tests, 200 Tests
Clone No:
L243
Synonyms:
HLA class II histocompatibility antigen DR alpha/ DRB1-15 beta chain;MHC class II antigen DRA;HLA-DRA1/DRB1;DRA/DRB1;
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P01903 P01911
Gene ID:
3122,3123
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kD α (heavy) chain and a 27 kD β (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells.
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