The Human HLA-DR Monoclonal Antibody FITC-Conjugated L243 (AGEL0415) offered by Assaygenie is a powerful tool for researchers studying the human HLA-DR protein. HLA-DR is a class II major histocompatibility complex (MHC) molecule that plays a crucial role in presenting antigens to T cells, thereby initiating the adaptive immune response.This monoclonal antibody, conjugated with FITC for fluorescence detection, specifically targets the HLA-DR protein, enabling precise detection and analysis in various experimental settings. Its high specificity and sensitivity make it ideal for applications such as flow cytometry, immunofluorescence, and immunohistochemistry in research areas including immunology, transplantation, infectious diseases, and autoimmunity.
By using the Human HLA-DR Monoclonal Antibody FITC-Conjugated L243 (AGEL0415), researchers can gain valuable insights into the expression, distribution, and function of HLA-DR molecules, furthering our understanding of immune responses and diseases related to MHC gene expression. Its reliability and performance make it a valuable asset for laboratories engaged in advanced immunological studies.
Product Title:
FITC Anti-Human HLA-DR Antibody [L243]
SKU:
AGEL0415
Size:
20 Tests, 100 Tests, 200 Tests
Clone No:
L243
Synonyms:
HLA class II histocompatibility antigen DR alpha/ DRB1-15 beta chain;MHC class II antigen DRA;HLA-DRA1/DRB1;DRA/DRB1;
Host Species:
Mouse
Reactivity:
Human
Application:
FCM
Isotype:
Mouse IgG2a, κ
Isotype Control:
FITC Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:
Liquid
Conjugation:
FITC
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P01903 P01911
Gene ID:
3122,3123
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kD α (heavy) chain and a 27 kD β (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells.
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