Human HEPACAM2 Recombinant Protein (RPPB3672)

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SKU:
RPPB3672
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
HEPACAM2
Synonyms:
HEPACAM family member 2 isoform 1
Synonyms:
MIKI
Synonyms:
HEPACAM family member 2
Synonyms:
Mitotic kinetics regulator
Source:
Escherichia Coli
Uniprot:
A8MVW5
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Description

Product Name:Human HEPACAM2 Recombinant Protein
Product Code:RPPB3672
Size:10µg
Species:Human
Target:HEPACAM2
Synonyms:HEPACAM family member 2 isoform 1, MIKI, HEPACAM family member 2, Mitotic kinetics regulator, HEPACAM2, UNQ305/PRO346.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The HEPACAM2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLKVTVPS HTVHGVRGQA LYLPVHYGFH TPASDIQIIW LFERPHTMPK YLLGSVNKSV VPDLEYQHKF TMMPPNASLL INPLQFPDEG NYIVKVNIQG NGTLSASQKI QVTVDDPVTK PVVQIHPPSG AVEYVGNMTL TCHVEGGTRL AYQWLKNGRP VHTSSTYSFS PQNNTLHIAP VTKEDIGNYS CLVRNPVSEM ESDIIMPIIY YGPYGLQVNS DKGLKVGEVF TVDLGEAILF DCSADSHPPN TYSWIRRTDN TTYIIKHGPR LEVASEKVAQ KTMDYVCCAY NNITGRQDET HFTVIITSVG LEKLAQKGKS LSP

HEPACAM2 is necessary during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, HEPACAM2 translocates from the Golgi apparatus to mitotic centrosomes and takes a significant part in the formation of robust microtubules for quick movement of chromosomes.

HEPACAM2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (32-351) and having a molecular mass of 37.9 kDa.HEPACAM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HEPACAM2: Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 7q21.3Cellular Component: centrosome; Golgi apparatus; midbody; spindleMolecular Function: protein bindingBiological Process: centrosome organization and biogenesis
UniProt Protein Details:
NCBI Summary:
UniProt Code:A8MVW5
NCBI GenInfo Identifier:187659944
NCBI Gene ID:253012
NCBI Accession:A8MVW5.1
UniProt Secondary Accession:A8MVW5,Q6UXI0, B3KTT4, B4DPJ1, B9EG93, E9PDV5
UniProt Related Accession:A8MVW5
Molecular Weight:54,115 Da
NCBI Full Name:HEPACAM family member 2
NCBI Synonym Full Names:HEPACAM family member 2
NCBI Official Symbol:HEPACAM2  
NCBI Official Synonym Symbols:MIKI  
NCBI Protein Information:HEPACAM family member 2
UniProt Protein Name:HEPACAM family member 2
UniProt Synonym Protein Names:Mitotic kinetics regulator
Protein Family:HEPACAM family
UniProt Gene Name:HEPACAM2  
UniProt Entry Name:HECA2_HUMAN
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