Human Hemopexin Recombinant Protein (RPPB3670)
- SKU:
- RPPB3670
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- Hemopexin
- Synonyms:
- Hemopexin
- Beta-1B-glycoprotein
- HPX
- Haemopexin
- Source:
- Escherichia Coli
- Uniprot:
- P02790
Description
| Product Name: | Human Hemopexin Recombinant Protein |
| Product Code: | RPPB3670 |
| Size: | 20µg |
| Species: | Human |
| Target: | Hemopexin |
| Synonyms: | Hemopexin, Beta-1B-glycoprotein, HPX, Haemopexin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The Hemopexin solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSTPLPPTS AHGNVAEGET KPDPDVTERC SDGWSFDATT LDDNGTMLFF KGEFVWKSHK WDRELISERW KNFPSPVDAA FRQGHNSVFL IKGDKVWVYP PEKKEKGYPK LLQDEFPGIP SPLDAAVECH RGECQAEGVL FFQGDREWFW DLATGTMKER SWPAVGNCSS ALRWLGRYYC FQGNQFLRFD PVRGEVPPRY PRDVRDYFMP CPGRGHGHRN GTGHGNSTHH GPEYMRCSPH LVLSALTSDN HGATYAFSGT HYWRLDTSRD GWHSWPIAHQ WPQGPSAVDA AFSWEEKLYL VQGTQVYVFL TKGGYTLVSG YPKRLEKEVG TPHGIILDSV DAAFICPGSS RLHIMAGRRL WWLDLKSGAQ ATWTELPWPH EKVDGALCME KSLGPNSCSA NGPGLYLIHG PNLYCYSDVE KLNAAKALPQ PQNVTSLLGC TH |
Hemopexin (or haemopexin) is a plasma protein that binds heme with the highest affinity of any known protein. Hemopexin is generally expressed in liver, and belongs to acute phase reactants, the synthesis of which is induced after inflammation. Heme is potentially very toxic because of its ability to intercalate into lipid membrane and to generate hydroxyl radicals. Hemopexin’s function of scavenging the heme released or lost by the turnover of heme proteins such as hemoglobin defends the body from the oxidative damage that free heme can cause. Additionally, hemopexin discharges its bound ligand for internalisation upon interacting with a specific receptor located on the surface of liver cells. This hemopexin function is in order to preserve the body's iron. Hemopexin’s levels in the serum are an indication of how much heme is present in the blood. Low Hemopexin levels show that there is a lot of it in the serum. For that reason, low hemopexin levels indicate that there has been consid
Hemopexin Human Recombinant produced in E. coli is. a single polypeptide chain containing 462 amino acids (24-462) and having a molecular mass of 51.7kDa. Hemopexin is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HPX: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Belongs to the hemopexin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11p15.5-p15.4 Cellular Component: extracellular space; extracellular region Molecular Function:protein binding; metal ion binding; heme transporter activity Biological Process: positive regulation of humoral immune response mediated by circulating immunoglobulin; receptor-mediated endocytosis; positive regulation of immunoglobulin production; heme transport; positive regulation of tyrosine phosphorylation of Stat1 protein; viral reproduction; hemoglobin metabolic process; cellular iron ion homeostasis; heme metabolic process |
| NCBI Summary: | This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009] |
| UniProt Code: | P02790 |
| NCBI GenInfo Identifier: | 11321561 |
| NCBI Gene ID: | 3263 |
| NCBI Accession: | NP_000604 |
| UniProt Secondary Accession: | P02790,B2R957, |
| UniProt Related Accession: | P02790 |
| Molecular Weight: | 51.7 kDa (462aa) |
| NCBI Full Name: | hemopexin |
| NCBI Synonym Full Names: | hemopexin |
| NCBI Official Symbol: | HPX |
| NCBI Official Synonym Symbols: | HX |
| NCBI Protein Information: | hemopexin |
| UniProt Protein Name: | Hemopexin |
| UniProt Synonym Protein Names: | Beta-1B-glycoprotein |
| Protein Family: | Hemopexin |
| UniProt Gene Name: | HPX |
| UniProt Entry Name: | HEMO_HUMAN |
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