Human HEBP1 Recombinant Protein (RPPB3668)

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SKU:
RPPB3668
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
HEBP1
Synonyms:
Heme-binding protein 1
Synonyms:
p22HBP
Synonyms:
HEBP1
Synonyms:
HBP
Source:
Escherichia Coli
Uniprot:
Q9NRV9
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Description

Product Name:Human HEBP1 Recombinant Protein
Product Code:RPPB3668
Size:10µg
Species:Human
Target:HEBP1
Synonyms:Heme-binding protein 1, p22HBP, HEBP1, HBP, HEBP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:HEBP1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMLGMIKN SLFGSVETWP WQVLSKGDKE EVAYEERACE GGKFATVEVT DKPVDEALRE AMPKVAKYAG GTNDKGIGMG MTVPISFAVF PNEDGSLQKK LKVWFRIPNQ FQSDPPAPSD KSVKIEEREG ITVYSMQFGG YAKEADYVAQ ATRLRAALEG TATYRGDIYF CTGYDPPMKP YGRRNEIWLL KT

Heme Binding Protein 1 (HEBP1) is an intracellular tetrapyrrole-binding protein. HEBP1 is comprised of a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and stimulates calcium mobilization and chemotaxis in monocytes and dendritic cells.

HEBP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (1-189 a.a.) and having a molecular mass of 23.5kDa.HEBP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HEBP1: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N- methylprotoporphyrin with similar affinities. Belongs to the HEBP family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 12p13.1

Cellular Component: extracellular region

Molecular Function:heme binding

Biological Process: circadian rhythm

NCBI Summary:The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NRV9
NCBI GenInfo Identifier:74734327
NCBI Gene ID:50865
NCBI Accession:Q9NRV9.1
UniProt Secondary Accession:Q9NRV9,Q9Y5Z5, A8K1G2,
UniProt Related Accession:Q9NRV9
Molecular Weight:21,097 Da
NCBI Full Name:Heme-binding protein 1
NCBI Synonym Full Names:heme binding protein 1
NCBI Official Symbol:HEBP1  
NCBI Official Synonym Symbols:HBP; HEBP  
NCBI Protein Information:heme-binding protein 1
UniProt Protein Name:Heme-binding protein 1
UniProt Synonym Protein Names:p22HBP
Protein Family:Heme-binding protein
UniProt Gene Name:HEBP1  
UniProt Entry Name:HEBP1_HUMAN
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