Human HBQ1 Recombinant Protein (RPPB3664)

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SKU:
RPPB3664
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
HBQ1
Synonyms:
Hemoglobin Theta 1
Synonyms:
Hemoglobin Theta-1 Chain
Synonyms:
Hemoglobin Subunit Theta-1
Synonyms:
Theta-1-globin
Source:
Escherichia Coli
Uniprot:
P09105
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Description

Product Name:Human HBQ1 Recombinant Protein
Product Code:RPPB3664
Size:20µg
Species:Human
Target:HBQ1
Synonyms:Hemoglobin Theta 1, Hemoglobin Theta-1 Chain, Hemoglobin Subunit Theta-1, Theta-1-globin.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The HBQ1 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMALSAED RALVRALWKK LGSNVGVYTT EALERTFLAF PATKTYFSHL DLSPGSSQVR AHGQKVADAL SLAVERLDDL PHALSALSHL HACQLRVDPA SFQLLGHCLL VTLARHYPGD FSPALQASLD KFLSHVISAL VSEYR

HBQ1 is a member of the Hemoglobin family. Hemoglobin is a 66.7 kDa protein attached to four iron-binding, methenelinked tetrapyrrole rings (heme). The globin part of Hemoglobin contains 2 alpha chains and 2 beta chains organized as couples creating a tetramer. Every one of the 4 globin chains covalently connects with a heme group. The bonds between alpha and beta chains are frailer than between parallel globin chains, thus creating a cleavage plane which is vital for oxygen binding and release. Relaxation of the alpha1-beta2 cleavage plane results in high affinity for oxygen.

HBQ1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (1-142) and having a molecular mass of 17.9kDa.HBQ1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HBQ1: Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: hemoglobin complexMolecular Function: iron ion binding; heme binding; oxygen binding; oxygen transporter activityBiological Process: oxygen transport
UniProt Protein Details:
NCBI Summary:Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]
UniProt Code:P09105
NCBI GenInfo Identifier:122330
NCBI Gene ID:3049
NCBI Accession:P09105.2
UniProt Secondary Accession:P09105,Q13723, Q1W6G5
UniProt Related Accession:P09105
Molecular Weight:
NCBI Full Name:Hemoglobin subunit theta-1
NCBI Synonym Full Names:hemoglobin, theta 1
NCBI Official Symbol:HBQ1  
NCBI Official Synonym Symbols:HBQ  
NCBI Protein Information:hemoglobin subunit theta-1; hemoglobin theta-1 chain; theta-1-globin
UniProt Protein Name:Hemoglobin subunit theta-1
UniProt Synonym Protein Names:Hemoglobin theta-1 chain; Theta-1-globin
Protein Family:Hemoglobin
UniProt Gene Name:HBQ1  
UniProt Entry Name:HBAT_HUMAN
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