Human GRO b Recombinant Protein (RPPB1146)
- SKU:
- RPPB1146
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- GRO b
- Synonyms:
- Macrophage inflammatory protein 2-alpha
- MIP2-alpha
- CXCL2
- Growth- regulated protein beta
- Source:
- Escherichia Coli
- Uniprot:
- P19875
Description
| Product Name: | Human GRO b Recombinant Protein |
| Product Code: | RPPB1146 |
| Size: | 10µg |
| Species: | Human |
| Target: | GRO b |
| Synonyms: | Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine (C-X-C motif) ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was lyophilized with no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized GRO-beta Human in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized CXCL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-Leu-Ala-Thr |
| Biological Activity: | The Biological activity is calculated by its ability to chemoattract CXCR2 transfected 293 cells using 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg. |
Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.
GRO-Beta Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7908 Dalton. The CXCL2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. |
| NCBI Summary: | This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P19875 |
| NCBI GenInfo Identifier: | 127085 |
| NCBI Gene ID: | 2920 |
| NCBI Accession: | P19875.1 |
| UniProt Secondary Accession: | P19875,Q6FGD6, Q9UPB8, |
| UniProt Related Accession: | P19875 |
| Molecular Weight: | 11,389 Da |
| NCBI Full Name: | C-X-C motif chemokine 2 |
| NCBI Synonym Full Names: | C-X-C motif chemokine ligand 2 |
| NCBI Official Symbol: | CXCL2 |
| NCBI Official Synonym Symbols: | GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a |
| NCBI Protein Information: | C-X-C motif chemokine 2 |
| UniProt Protein Name: | C-X-C motif chemokine 2 |
| UniProt Synonym Protein Names: | Growth-regulated protein beta; Gro-beta |
| Protein Family: | C-X-C motif chemokine |
| UniProt Gene Name: | CXCL2 |
| UniProt Entry Name: | CXCL2_HUMAN |
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