Human GHBP Recombinant Protein (RPPB0347)
- SKU:
- RPPB0347
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- GHBP
- Source:
- Escherichia Coli
- Uniprot:
- P10912
Description
| Product Name: | Human GHBP Recombinant Protein |
| Product Code: | RPPB0347 |
| Size: | 20µg |
| Species: | Human |
| Target: | GHBP |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | GHBP was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3. |
| Solubility: | It is recommended to reconstitute the lyophilized GHBP in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GHBP although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GHBP should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | AFSGSEATAAILSRAPWSLQSVNPGLKTNS SKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSA GENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGI HADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYE VRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYF |
| Biological Activity: | GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with G.H. |
GHBP is a transmembrane receptor for GH. Binding of GH to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the GH insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.
GHBP Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 248 amino acids and having a molecular mass of 28107.01 Dalton. GHR is purified by proprietary chromatographic techniques.
| UniProt Code: | P10912 |
| NCBI GenInfo Identifier: | 121180 |
| NCBI Gene ID: | 2690 |
| NCBI Accession: | P10912.1 |
| UniProt Secondary Accession: | P10912,Q9HCX2, |
| UniProt Related Accession: | P10912 |
| Molecular Weight: | 638 |
| NCBI Full Name: | Growth hormone receptor |
| NCBI Synonym Full Names: | growth hormone receptor |
| NCBI Official Symbol: | GHR |
| NCBI Official Synonym Symbols: | GHBP |
| NCBI Protein Information: | growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein |
| UniProt Protein Name: | Growth hormone receptor |
| UniProt Synonym Protein Names: | Somatotropin receptorGrowth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein |
| Protein Family: | Ghrelin |
| UniProt Gene Name: | GHR |
| UniProt Entry Name: | GHR_HUMAN |
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