Human GFRA3 Recombinant Protein (RPPB0300)

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SKU:
RPPB0300
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
GFRA3
Synonyms:
GDNF Family Receptor Alpha3
Synonyms:
GDNFR-alpha-3
Synonyms:
GFR-alpha-3
Synonyms:
GDNFReceptor Alpha-3
Source:
Escherichia Coli
Uniprot:
O60609
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Description

Product Name:Human GFRA3 Recombinant Protein
Product Code:RPPB0300
Size:20µg
Species:Human
Target:GFRA3
Synonyms:GDNF Family Receptor Alpha3, GDNFR-alpha-3, GFR-alpha-3, GDNFReceptor Alpha-3, GDNFR3, GDNF Family Receptor Alpha-3, Glial Cell Line-DerivedNeurotrophic Factor Receptor Alpha-3, GPI-Linked Receptor.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:GFRA3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSDPLPTES RLMNSCLQAR RKCQADPTCS AAYHHLDSCT SSISTPLPSE EPSVPADCLE AAQQLRNSSL IGCMCHRRMK NQVACLDIYW TVHRARSLGN YELDVSPYED TVTSKPWKMN LSKLNMLKPD SDLCLKFAML CTLNDKCDRL RKAYGEACSGPHCQRHVCLR QLLTFFEKAA EPHAQGLLLC PCAPNDRGCG ERRRNTIAPN CALPPVAPNC LELRRLCFSD PLCRSRLVDF QTHCHPMDIL GTCATEQSRC LRAYLGLIGT AMTPNFVSNV NTSVALSCTC RGSGNLQEEC EMLEGFFSHN PCLTEAIAAK MRFHSQLFSQ DWPHPTFAVMAHQNEN

GDNFFamily Receptor Alpha 3 (GFRA3) belongs to the GDNF receptor family. GFRA3creates a signaling receptor complex with RET tyrosine kinase receptor andbinds the ligand, artemin (ARTN).

GFRA3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 366 amino acids (32-374a.a) and having a molecular mass of 40.7kDa.GFRA3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GFRA3: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 5q31.1-q31.3

Cellular Component: extrinsic to membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function:axon guidance receptor activity; receptor binding

Biological Process: axon guidance; nervous system development; sympathetic nervous system development; neuron migration; signal transduction; peripheral nervous system development

NCBI Summary:The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]
UniProt Code:O60609
NCBI GenInfo Identifier:50403696
NCBI Gene ID:2676
NCBI Accession:O60609.2
UniProt Related Accession:O60609
Molecular Weight:Observed Molecular Weight: (Observed)44kD.Predicted Molecular Weight: (Calculated)45kDa.
NCBI Full Name:GDNF family receptor alpha-3
NCBI Synonym Full Names:GDNF family receptor alpha 3
NCBI Official Symbol:GFRA3  
NCBI Official Synonym Symbols:GDNFR3  
NCBI Protein Information:GDNF family receptor alpha-3
UniProt Protein Name:GDNF family receptor alpha-3
Protein Family:GDNF family receptor
UniProt Gene Name:GFRA3  
UniProt Entry Name:GFRA3_HUMAN
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