Human GDNF Recombinant Protein (RPES4945)

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SKU:
RPES4945
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human GDNF Recombinant Protein

Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a disulfide-linked homodimeric glycoprotein that belongs to the TGF-β superfamily. It has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. Mutations in this gene may be associated with Hirschsprung disease.

Product Name:Human GDNF Recombinant Protein (RPES4945)
Product Code:RPES4945
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Glial Cell Line-Derived Neurotrophic Factor, hGDNF, Astrocyte-Derived Trophic Factor, ATF, GDNF
Accession:P39905
Sequence:Ser78-Ile211
Fusion tag:
Activity:Immobilized Human GDNF at 2µg/ml(100 ?l/well) can bind Human GFRA1-His(Cat: PKSH033670).
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Glial Cell Line-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ser78-Ile211 is expressed.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:15.1 kDa
AP Mol Mass:17 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.25.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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