Human GDF11 Recombinant Protein (RPPB0310)
- SKU:
- RPPB0310
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- GDF11
- Synonyms:
- Growth Differentiation Factor 11
- GDF-11
- Bone Morphogenetic Protein 11
- BMP11
- Source:
- Escherichia Coli
- Uniprot:
- O95390
Description
| Product Name: | Human GDF11 Recombinant Protein |
| Product Code: | RPPB0310 |
| Size: | 20µg |
| Species: | Human |
| Target: | GDF11 |
| Synonyms: | Growth Differentiation Factor 11, GDF-11, Bone Morphogenetic Protein 11, BMP11. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution containing 0.1% Trifluoroacetic Acid (TFA). |
| Solubility: | It is recommended to reconstitute the lyophilized GDF11 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GDF11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF11 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHLVQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS |
| Biological Activity: | The ED50 as determined by the ability to inhibit alkaline phosphatase activity in ATDC5 cells, is 0.2-0.3ng/ml, corresponding to a specific activity of 5 x 106units/mg. |
GDF-11 belongs to the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. GDF-11 is a central developmental factor which controls muscular and neural development. In adults, GDF-11 encourages cardiac hypertrophy reverse by the revival of cardiomyocytes.
GDF11 Human Recombinant produced in E.Coli is a non-glycosylated homodimer containing 2x109 amino acids and having a total molecular mass of 24.9kDa.
| UniProt Protein Function: | GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 12q13.2 Cellular Component: extracellular space; intracellular membrane-bound organelle; nucleoplasm; protein complex Molecular Function:cytokine activity; growth factor activity; transforming growth factor beta receptor binding Biological Process: camera-type eye morphogenesis; cell development; cell maturation; growth; mesoderm development; metanephros development; negative regulation of cell proliferation; negative regulation of neuron differentiation; nervous system development; palate development; pancreas development; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development; spinal cord anterior/posterior patterning; ureteric bud development |
| NCBI Summary: | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95390 |
| NCBI GenInfo Identifier: | 12643335 |
| NCBI Gene ID: | 10220 |
| NCBI Accession: | O95390.1 |
| UniProt Secondary Accession: | O95390,Q9UID1, Q9UID2, |
| UniProt Related Accession: | O95390 |
| Molecular Weight: | 45,091 Da |
| NCBI Full Name: | Growth/differentiation factor 11 |
| NCBI Synonym Full Names: | growth differentiation factor 11 |
| NCBI Official Symbol: | GDF11 |
| NCBI Official Synonym Symbols: | BMP11; BMP-11 |
| NCBI Protein Information: | growth/differentiation factor 11 |
| UniProt Protein Name: | Growth/differentiation factor 11 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 11; BMP-11 |
| UniProt Gene Name: | GDF11 |
| UniProt Entry Name: | GDF11_HUMAN |
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