Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently; we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here; we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module; a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation; in part; through BMP4 signaling.
Product Name:
Human FSTL1 Recombinant Protein (RPES3380)
Product Code:
RPES3380
Size:
50µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
FRP,FSL1,MIR198
Accession:
NP_009016.1
Sequence:
Met 1-Ile 308
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human FSTL1 (NP_009016.1) precursor (Met 1-Ile 308) with a carboxy-terminal polyhistidine tag was expressed.
Purity:
> 98 % as determined by reducing SDS-PAGE.
Mol Mass:
34.2 kDa
AP Mol Mass:
47 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
