Human FST Recombinant Protein (RPPB0264)
- SKU:
- RPPB0264
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- FST
- Synonyms:
- FST
- FS
- Activin-binding protein
- Source:
- Escherichia Coli
- Uniprot:
- P19883
Description
| Product Name: | Human FST Recombinant Protein |
| Product Code: | RPPB0264 |
| Size: | 10µg |
| Species: | Human |
| Target: | FST |
| Synonyms: | FST, FS, Activin-binding protein. |
| Source: | Escherichia Coli |
| Formulation: | FST His Tag was filtered (0.4µm) and lyophilized from 0.5mg/ml supplied in 20mM TRIS and 20mM NaCl, pH 7.5. |
| Solubility: | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture. |
| Stability: | Store lyophilized FST His at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted FST His can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Amino Acid Sequence: | MKHHHHHHAS GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTLFKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA PDCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKKTCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DGVTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCLWD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AACSSGVLLE VKHSGSCNSI SEDTEEEEED EDQDYSFPIS SILEW |
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).
FST His Protein is 36.0 kDa protein containing 325 amino acid residues of the FST His and the 10 aa N-Terminal His-tag.
| UniProt Protein Function: | FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q11.2 Cellular Component: cytoplasm; extracellular region; nucleus Molecular Function:heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding Biological Process: BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; keratinocyte proliferation; negative regulation of transcription from RNA polymerase II promoter; pattern specification process; skeletal development; female gonad development; odontogenesis of dentine-containing teeth Disease: Polycystic Ovary Syndrome 1 |
| NCBI Summary: | Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P19883 |
| NCBI GenInfo Identifier: | 23831079 |
| NCBI Gene ID: | 10468 |
| NCBI Accession: | P19883.2 |
| UniProt Secondary Accession: | P19883,Q9BTH0, B5BU94, |
| UniProt Related Accession: | P19883 |
| Molecular Weight: | 34,803 Da |
| NCBI Full Name: | Follistatin |
| NCBI Synonym Full Names: | follistatin |
| NCBI Official Symbol: | FST |
| NCBI Official Synonym Symbols: | FS |
| NCBI Protein Information: | follistatin; activin-binding protein; follistatin isoform FST317 |
| UniProt Protein Name: | Follistatin |
| UniProt Synonym Protein Names: | Activin-binding protein |
| Protein Family: | Follistatin |
| UniProt Gene Name: | FST |
| UniProt Entry Name: | FST_HUMAN |
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