Human FST Recombinant Protein (RPPB0263)

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SKU:
RPPB0263
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
FST
Synonyms:
FST
Synonyms:
FS
Source:
Escherichia Coli
Uniprot:
P19883
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Description

Product Name:Human FST Recombinant Protein
Product Code:RPPB0263
Size:20µg
Species:Human
Target:FST
Synonyms:FST, FS
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a concentrated (1mg/ml) solution containing no additives.
Solubility:It is recommended to reconstitute the lyophilized Follistatin in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Follistatin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Gly-Asn-Cys-Trp-Leu
Biological Activity:The activity is determined by the ability to neutralize ACTV inhibitory effect of mouse MPC-11 cells. The expected ED50 is 100-400ng/ml, corresponding to a Specific Activity of 2,500-10,000units/mg in the presence of 7.5ng/ml ACTV A.

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin  functions as an ACTV antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).

Follistatin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids and having a total molecular mass of 31.5kDa.The FST is purified by proprietary chromatographic techniques.

UniProt Protein Function:FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: cytoplasm; extracellular region; nucleus

Molecular Function:heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding

Biological Process: BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; keratinocyte proliferation; negative regulation of transcription from RNA polymerase II promoter; pattern specification process; skeletal development; female gonad development; odontogenesis of dentine-containing teeth

Disease: Polycystic Ovary Syndrome 1

NCBI Summary:Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
UniProt Code:P19883
NCBI GenInfo Identifier:23831079
NCBI Gene ID:10468
NCBI Accession:P19883.2
UniProt Secondary Accession:P19883,Q9BTH0, B5BU94,
UniProt Related Accession:P19883
Molecular Weight:34,803 Da
NCBI Full Name:Follistatin
NCBI Synonym Full Names:follistatin
NCBI Official Symbol:FST  
NCBI Official Synonym Symbols:FS  
NCBI Protein Information:follistatin; activin-binding protein; follistatin isoform FST317
UniProt Protein Name:Follistatin
UniProt Synonym Protein Names:Activin-binding protein
Protein Family:Follistatin
UniProt Gene Name:FST  
UniProt Entry Name:FST_HUMAN
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