Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Furthermore, EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 protein has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Therefore, Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.
Product Name:
Human EphB4/HTK Recombinant Protein (RPES1970)
Product Code:
RPES1970
Size:
20µg
Species:
Human
Expressed Host:
Baculovirus-Insect Cells
Synonyms:
HTK,MYK1,TYRO11
Accession:
P54760
Sequence:
Leu563-Tyr987
Fusion tag:
N-His & GST
Activity:
The specific activity was determined to be 47 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human EPHB4 (P54760) (Leu563-Tyr987) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
