Human EBAG9 Recombinant Protein (RPPB3386)

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SKU:
RPPB3386
Product type:
Recombinant Protein
Size:
50ug
Species:
Human
Target:
EBAG9
Synonyms:
EB9
Synonyms:
PDAF
Synonyms:
RCAS1
Synonyms:
EBAG9
Source:
Escherichia Coli
Uniprot:
O00559
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Description

Product Name:Human EBAG9 Recombinant Protein
Product Code:RPPB3386
Size:50µg
Species:Human
Target:EBAG9
Synonyms:EB9, PDAF, RCAS1, EBAG9, Receptor-binding cancer antigen expressed on SiSo cells, Cancer-associated surface antigen RCAS1, Estrogen receptor-binding fragment-associated gene 9 protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The EBAG9 protein solution contains 20mM Tris-HCl pH-8, 1mM DTT, 2mM EDTA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MRSGRGRKLS GDQITLPTTV DYSSVPKQTD VEEWTSWDED APTSVKIEGG NGNVATQQNS LEQLEPDYFK DMTPTIRKTQ KIVIKKREPL NFGIPDGSTG FSSRLAATQD LPFIHQSSEL GDLDTWQENT NAWEEEEDAA WQAEEVLRQQ KLADREKRAA EQQRKKMEKE AQRLMKKEQN KIGVKLS

EBAG9 is a type III transmembrane protein that is primarily located in the Golgi. EBAG9 is a tumor-associated antigen that is expressed at high frequency in a variety of cancers, such as advanced breast and prostate cancers. while the EBAG9 acts to inhibit the growth of receptor-binding cells and induced apoptosis of immune cells, cancer cells may evade immune surveillance. Thus immunodetection of EBAG9 expression can be a negative prognostic indicator. EBAG9 promotes progression of bladder cancer. In rheumatoid arthritis, the deficiency of EBAG9 induces CTL infiltration through failure to evade immune attack, therefore leading to apoptosis of the synovial lining cells. EBAG9 is involved in controlling exocytosis processes. EBAG9 expression plays a role in the progression of oral squamous cell carcinoma. EBAG9 plays a specific role in premature stages of breast carcinogenesis.

EBAG9 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 207 amino acids (28-213) and having a molecular mass of 23.4 kDa. The EBAG9 protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography techniques.

UniProt Protein Function:RCAS1: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases. Homodimer. By estrogen. Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.
UniProt Protein Details:

Protein type:Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 8q23

Cellular Component: Golgi membrane; Golgi apparatus; focal adhesion; plasma membrane; integral to membrane; secretory granule

Molecular Function:apoptotic protease activator activity

Biological Process: apoptosis; regulation of cell growth

UniProt Code:O00559
NCBI GenInfo Identifier:8928283
NCBI Gene ID:
NCBI Accession:O00559.1
Molecular Weight:
NCBI Full Name:Receptor-binding cancer antigen expressed on SiSo cells
UniProt Protein Name:Receptor-binding cancer antigen expressed on SiSo cells
UniProt Synonym Protein Names:Cancer-associated surface antigen RCAS1; Estrogen receptor-binding fragment-associated gene 9 protein
Protein Family:Receptor-binding cancer antigen
UniProt Gene Name:EBAG9  
UniProt Entry Name:RCAS1_HUMAN
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