Human DUSP13 Recombinant Protein (RPPB1592)

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SKU:
RPPB1592
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
DUSP13
Synonyms:
Dual specificity protein phosphatase 13
Synonyms:
Dual specificity phosphatase SKRP4
Synonyms:
Testis- and skeletal-muscle-specific DSP
Synonyms:
DUSP13
Source:
Escherichia Coli
Uniprot:
Q9UII6
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Description

Product Name:Human DUSP13 Recombinant Protein
Product Code:RPPB1592
Size:10µg
Species:Human
Target:DUSP13
Synonyms:Dual specificity protein phosphatase 13, Dual specificity phosphatase SKRP4, Testis- and skeletal-muscle-specific DSP, DUSP13, TMDP, BEDP, MDSP, SKRP4, DUSP13A, DUSP13B.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The DUSP13 solution (0.5mg/ml) contains 20mM Tris-HCl buffer, pH8.0, 10% glycerol, 2mM DTT and 50mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMDSLQK QDLRRPKIHG AVQASPYQPP TLASLQRLLW VRQAATLNHI DEVWPSLFLG DAYAARDKSK LIQLGITHVV NAAAGKFQVD TGAKFYRGMS LEYYGIEADD NPFFDLSVYF LPVARYIRAA LSVPQGRVLV HCAMGVSRSA TLVLAFLMIC ENMTLVEAIQ TVQAHRNICP NSGFLRQLQV LDNRLGRETG RF

Dual specificity phosphatase 13 (DUSP13) is a member of the protein-tyrosine phosphatase family. DUSP13 cooperates with protein kinases to control cell proliferation and differentiation. DUSP13 is engaged in the regulation of meiosis and/or differentiation of testicular germ cells in the course of spermatogenesis. DUSP13 demonstrates intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues of myelin basic protein, with similar specific activities in vitro.

DUSP13 Human Recombinant produced in E. coli is a single polypeptide chain containing 222 amino acids (1-198) and having a molecular mass of 24.7kDa.DUSP13 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DUSP13: May be involved in the regulation of meiosis and/or differentiation of testicular germ cells during spermatogenesis. Exhibits intrinsic phosphatase activity towards both phospho- seryl/threonyl and -tyrosyl residues of myelin basic protein, with similar specific activities in vitro. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 5 isoforms of the human protein are produced by alternative promoter.
UniProt Protein Details:

Protein type:EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; Cell cycle regulation; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: cytoplasm

Molecular Function:protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: meiosis; spermatogenesis; protein amino acid dephosphorylation

NCBI Summary:Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UII6
NCBI GenInfo Identifier:257051044
NCBI Gene ID:51207
NCBI Accession:Q9UII6.3
UniProt Secondary Accession:Q9UII6,Q5JSC6, Q6IAR0, Q96GC2, A8K776, A8K782, B3KPY1 B3KXT0, B4DUK0,
UniProt Related Accession:Q6B8I1,Q9UII6
Molecular Weight:198
NCBI Full Name:Dual specificity protein phosphatase 13 isoform B
NCBI Synonym Full Names:dual specificity phosphatase 13
NCBI Official Symbol:DUSP13  
NCBI Official Synonym Symbols:BEDP; MDSP; TMDP; SKRP4; DUSP13A; DUSP13B  
NCBI Protein Information:dual specificity protein phosphatase 13; muscle-restricted DSP; branching-enzyme interacting DSP; testis- and skeletal-muscle-specific DSP; branching-enzyme interacting dual-specificity protein phosphatase
UniProt Protein Name:Dual specificity protein phosphatase 13 isoform B
UniProt Synonym Protein Names:Dual specificity phosphatase SKRP4; Testis- and skeletal-muscle-specific DSP
Protein Family:Dual specificity protein phosphatase
UniProt Gene Name:DUSP13  
UniProt Entry Name:DS13B_HUMAN
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