Human DLST Recombinant Protein (RPPB1579)
- SKU:
- RPPB1579
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- DLST
- Synonyms:
- dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
- Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
- component E2
- DLST
- Source:
- Sf9 Insect cells
- Uniprot:
- P36957
Description
| Product Name: | Human DLST Recombinant Protein |
| Product Code: | RPPB1579 |
| Size: | 10µg |
| Species: | Human |
| Target: | DLST |
| Synonyms: | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, component E2, DLST, E2K, OGDC-E2, EC 2.3.1.61, EC 2.3.1. |
| Source: | Sf9 Insect cells |
| Formulation: | DLST (0.74mg/ml) is supplied in 20mM HEPES buffer pH-8.0, 200mM NaCl and 20% glycerol. |
| Stability: | Store DLST at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | DLST purity was found to be greater than 75% as determined by SDS-PAGE. |
DLST catalyzes the general transformation of 2-oxoglutarate to succinyl-CoA and CO(2). DLST holds multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
DLST is a Full-length cDNA coding for the mature form of the human OGDC-E2 protein having a molecular mass of 42,301 Dalton (pH 6.3).DLST protein is fused to a hexa-histidine purification tag.
| UniProt Protein Function: | DLST: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Forms a 24-polypeptide structural core with octahedral symmetry. Belongs to the 2-oxoacid dehydrogenase family. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - lysine degradation; Transferase; Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.1.61; Mitochondrial Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: membrane; mitochondrial matrix; oxoglutarate dehydrogenase complex; nucleus Molecular Function:dihydrolipoyllysine-residue succinyltransferase activity Biological Process: cellular metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle; L-lysine catabolic process to acetyl-CoA via saccharopine; lysine catabolic process |
| NCBI Summary: | This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P36957 |
| NCBI GenInfo Identifier: | 317373578 |
| NCBI Gene ID: | 1743 |
| NCBI Accession: | P36957.4 |
| UniProt Secondary Accession: | P36957,Q7LDY7, Q9BQ32, |
| UniProt Related Accession: | P36957 |
| Molecular Weight: | 48,755 Da |
| NCBI Full Name: | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
| NCBI Synonym Full Names: | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) |
| NCBI Official Symbol: | DLST |
| NCBI Official Synonym Symbols: | DLTS |
| NCBI Protein Information: | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; E2K; OGDC-E2 |
| UniProt Protein Name: | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
| UniProt Synonym Protein Names: | 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K |
| Protein Family: | Serine transporter |
| UniProt Gene Name: | DLST |
| UniProt Entry Name: | ODO2_HUMAN |
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