Human DHPS Recombinant Protein (RPPB1573)

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SKU:
RPPB1573
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
DHPS
Synonyms:
MIG13
Synonyms:
EC 25146
Synonyms:
Deoxyhypusine synthase
Synonyms:
DHS
Source:
Escherichia Coli
Uniprot:
P49366
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Description

Product Name:Human DHPS Recombinant Protein
Product Code:RPPB1573
Size:25µg
Species:Human
Target:DHPS
Synonyms:MIG13, EC 2.5.1.46, Deoxyhypusine synthase, DHS, DHPS, DS.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear colorless solution.
Formulation:The DHPS solution contains 20mM Tris-HCl pH-8, 0.1M NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEGSLEREAP AGALAAVLKH SSTLPPESTQ VRGYDFNRGV NYRALLEAFG TTGFQATNFG RAVQQVNAMI EKKLEPLSQD EDQHADLTQS RRPLTSCTIF LGYTSNLISS GIRETIRYLV QHNMVDVLVT TAGGVEEDLI KCLAPTYLGE FSLRGKELRE NGINRIGNLL VPNENYCKFE DWLMPILDQM VMEQNTEGVK WTPSKMIARL GKEINNPESV YYWAQKNHIP VFSPALTDGS LGDMIFFHSY KNPGLVLDIV EDLRLINTQA IFAKCTGMII LGGGVVKHHI ANANLMRNGA DYAVYINTAQ EFDGSDSGAR PDEAVSWGKI RVDAQPVKVY ADASLVFPLL VAETFAQKMD AFMHEKNED

DHPS is vital for the first step of hypusine biosynthesis. DHPS catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue.

DHPS Human Recombinant fused to 20 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 389 amino acids (1-369 a.a.) and having a molecular mass of 43.1 kDa. The DHPS is purified by proprietary chromatographic techniques.

UniProt Protein Function:DHPS: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. Belongs to the deoxyhypusine synthase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation; EC 2.5.1.46; Transferase

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytosol

Molecular Function:deoxyhypusine synthase activity; protein binding

Biological Process: hypusine biosynthetic process from peptidyl-lysine; positive regulation of cell proliferation; translation

NCBI Summary:This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]
UniProt Code:P49366
NCBI GenInfo Identifier:1352267
NCBI Gene ID:1725
NCBI Accession:P49366.1
UniProt Secondary Accession:P49366,Q13184, Q13276, Q9UDG0, A8K688, M0R1I5,
UniProt Related Accession:P49366
Molecular Weight:36,583 Da
NCBI Full Name:Deoxyhypusine synthase
NCBI Synonym Full Names:deoxyhypusine synthase
NCBI Official Symbol:DHPS  
NCBI Official Synonym Symbols:DS; DHS; MIG13  
NCBI Protein Information:deoxyhypusine synthase
UniProt Protein Name:Deoxyhypusine synthase
UniProt Gene Name:DHPS  
UniProt Entry Name:DHYS_HUMAN
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