Human DCAF7 Recombinant Protein (RPPB3332)

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SKU:
RPPB3332
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
DCAF7
Synonyms:
DDB1- and CUL4-associated factor 7
Synonyms:
WD repeat-containing protein 68
Synonyms:
WD repeat-containing protein An11 homolog
Synonyms:
DCAF7
Source:
Escherichia Coli
Uniprot:
P61962
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Description

Product Name:Human DCAF7 Recombinant Protein
Product Code:RPPB3332
Size:20µg
Species:Human
Target:DCAF7
Synonyms:DDB1- and CUL4-associated factor 7, WD repeat-containing protein 68, WD repeat-containing protein An11 homolog, DCAF7, HAN11, WDR68, AN11, SWAN-1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:DCAF7 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M urea and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MVYAMNWSVR PDKRFRLALG SFVEEYNNKV QLVGLDEESS EFICRNTFDH PYPTTKLMWI PDTKGVYPDL LATSGDYLRV WRVGETETRL ECLLNNNKNS DFCAPLTSFD WNEVDPYLLG TSSIDTTCTI WGLETGQVLG RVNLVSGHVK TQLIAHDKEV YDIAFSRAGG GRDMFASVGA DGSVRMFDLR HLEHSTIIYE DPQHHPLLRL CWNKQDPNYL ATMAMDGMEV VILDVRVPCT PVARLNNHRA CVNGIAWAPH SSCHICTAAD DHQALIWD

DDB1-and CUL4-associated factor (DCAF7) is involved in craniofacial development. The DCAF7 protein acts upstream of the EDN1 pathway and is essential for formation of the upper jaw equivalent, the palatoquadrate. The activity necessary for the EDN1 pathway function varies between the first and second arches. DCAF7 associates with DIAPH1 and controls GLI1 transcriptional activity. DCAF7 may be involved in normal and diseased skin development.

DCAF7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids (19-295 a.a) and having a molecular mass of 33.6kDa.DCAF7 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:WDR68: a WD40 repeat protein. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: cytoplasm; nuclear matrix; nucleoplasm; protein complex

Molecular Function:protein binding

Biological Process: protein ubiquitination

NCBI Summary:This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Code:P61962
NCBI GenInfo Identifier:48428729
NCBI Gene ID:10238
NCBI Accession:P61962.1
UniProt Secondary Accession:P61962,O15491, Q9DAE4, B4E039, D3DU14,
UniProt Related Accession:P61962
Molecular Weight:16,340 Da
NCBI Full Name:DDB1- and CUL4-associated factor 7
NCBI Synonym Full Names:DDB1 and CUL4 associated factor 7
NCBI Official Symbol:DCAF7  
NCBI Official Synonym Symbols:AN11; HAN11; WDR68; SWAN-1  
NCBI Protein Information:DDB1- and CUL4-associated factor 7
UniProt Protein Name:DDB1- and CUL4-associated factor 7
UniProt Synonym Protein Names:WD repeat-containing protein 68; WD repeat-containing protein An11 homolog
Protein Family:DDB1- and CUL4-associated factor
UniProt Gene Name:DCAF7  
UniProt Entry Name:DCAF7_HUMAN
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