Human DAP Recombinant Protein (RPPB3326)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB3326
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
DAP
Synonyms:
Death-associated protein 1
Synonyms:
DAP-1
Synonyms:
DAP
Synonyms:
DAP1
Source:
Escherichia Coli
Uniprot:
P51397
€0.00
Frequently bought together:

Description

Product Name:Human DAP Recombinant Protein
Product Code:RPPB3326
Size:10µg
Species:Human
Target:DAP
Synonyms:Death-associated protein 1, DAP-1, DAP, DAP1, Death-Associated Protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:DAP protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greaterthan 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSSPPEG KLETKAGHPP AVKAGGMRIV QKHPHTGDTK EEKDKDDQEW ESPSPPKPTV FISGVIARGD KDFPPAAAQV AHQKPHASMD KHPSPRTQHI QQPRK

Death-Associated Protein (DAP) is a proline-rich protein. DAP, which is a negative regulator of autophagy, takes part in the mediation of IFN-gamma-induced cell death.

DAP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 125 amino acids (1-102 a.a.) and having a molecular mass of 13.6kDa.DAP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DAP: a 15 kDa, proline rich protein that possesses one SH3 binding motif. Negatively regulates autophagy and is involved in mediating interferon-gamma-induced cell death. Localizes in the cytoplasm, but the detailed mechanism of its proapoptotic function is unclear.
UniProt Protein Details:

Protein type:Autophagy

Chromosomal Location of Human Ortholog: 5p15.2

Biological Process: apoptosis; caspase activation; cellular response to amino acid starvation; inhibition of NF-kappaB transcription factor; negative regulation of autophagy; negative regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
UniProt Code:P51397
NCBI GenInfo Identifier:1706298
NCBI Gene ID:1611
NCBI Accession:P51397.3
UniProt Secondary Accession:P51397,Q6FGC3, Q9BUC9,
UniProt Related Accession:P51397
Molecular Weight:11,165 Da
NCBI Full Name:Death-associated protein 1
NCBI Synonym Full Names:death associated protein
NCBI Official Symbol:DAP  
NCBI Protein Information:death-associated protein 1
UniProt Protein Name:Death-associated protein 1
Protein Family:Dapper
UniProt Gene Name:DAP  
UniProt Entry Name:DAP1_HUMAN
View AllClose

Related Products