Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family; which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes; including intracellular signaling; transcription; inflammation; and apoptosis. Cyclophilin is also incorporated into many viruses; including HIV1; where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin; making it a useful inhibitor for studying calcineurin activity.
Product Name:
Human Cyclophilin A Recombinant Protein (RPES3919)
Product Code:
RPES3919
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A, SP18, PPIA, CYPA
Accession:
P62937
Sequence:
Met 1-Glu165
Fusion tag:
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Peptidyl-prolyl Cis-trans Isomerase A is produced by our E.coli expression system and the target gene encoding Met1-Glu165 is expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
18 kDa
AP Mol Mass:
16 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of PBS; 10%glycerol;pH7.4.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
