Human CTNNBIP1 Recombinant Protein (RPPB3308)

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SKU:
RPPB3308
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
CTNNBIP1
Synonyms:
ICAT
Synonyms:
MGC15093
Synonyms:
CNBP1
Synonyms:
CTNNBIP1
Source:
Escherichia Coli
Uniprot:
Q9NSA3
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Description

Product Name:Human CTNNBIP1 Recombinant Protein
Product Code:RPPB3308
Size:25µg
Species:Human
Target:CTNNBIP1
Synonyms:ICAT, MGC15093, CNBP1, CTNNBIP1, Beta-catenin-interacting protein 1, Inhibitor of beta-catenin and Tcf-4.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:CTNNBIP1 Human solution containing 20mM Tris-HCl pH-7.5, 2mM DTT, 0.1M NaCl & 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q

CTNNBIP1 binds CTNNB1 and avoids interaction between CTNNB1 and TCF (T-cell transcription factor) family members. CTNNBIP1 is a negative regulator of the Wnt signaling pathway.

CTNNBIP1 Recombinant E.coli produced in E.Coli is a single, non-glycosylated polypeptide chain containing 101 amino acids (1-81 a.a.) and having a molecular mass of 11.3 kDa. The CTNNBIP1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CTNNBIP1: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Belongs to the CTNNBIP1 family.
UniProt Protein Details:

Protein type:Cell development/differentiation; Inhibitor

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; cytoplasm; nucleus; beta-catenin destruction complex; cytosol

Molecular Function:protein binding; beta-catenin binding

Biological Process: anterior/posterior pattern formation; positive regulation of monocyte differentiation; positive regulation of osteoblast differentiation; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; ureteric bud branching; negative regulation of smooth muscle cell proliferation; negative regulation of transcription factor activity; negative regulation of protein binding; regulation of vascular permeability during acute inflammatory response; negative regulation of DNA binding

NCBI Summary:The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NSA3
NCBI GenInfo Identifier:59889555
NCBI Gene ID:56998
NCBI Accession:NP_001012329.1
UniProt Secondary Accession:Q9NSA3,Q9JJN6,
UniProt Related Accession:Q9NSA3
Molecular Weight:9,170 Da
NCBI Full Name:beta-catenin-interacting protein 1
NCBI Synonym Full Names:catenin, beta interacting protein 1
NCBI Official Symbol:CTNNBIP1  
NCBI Official Synonym Symbols:ICAT  
NCBI Protein Information:beta-catenin-interacting protein 1; beta-catenin-interacting protein ICAT; inhibitor of beta-catenin and Tcf-4
UniProt Protein Name:Beta-catenin-interacting protein 1
UniProt Synonym Protein Names:Inhibitor of beta-catenin and Tcf-4
UniProt Gene Name:CTNNBIP1  
UniProt Entry Name:CNBP1_HUMAN
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