Human CSNK2A2 Recombinant Protein (RPPB2495)

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SKU:
RPPB2495
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CSNK2A2
Synonyms:
CaseinKinase 2
Synonyms:
Alpha Prime Polypeptide
Synonyms:
CK II Alpha
Synonyms:
EC 27111
Source:
Escherichia Coli
Uniprot:
P19784
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Description

Product Name:Human CSNK2A2 Recombinant Protein
Product Code:RPPB2495
Size:10µg
Species:Human
Target:CSNK2A2
Synonyms:CaseinKinase 2, Alpha Prime Polypeptide, CK II Alpha, EC 2.7.11.1, CK2A2, EC 2.7.11, CSNK2A1,Casein kinase II subunit alpha'.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CSNK2A2 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMPGPAA GSRARVYAEV NSLRSREYWD YEAHVPSWGN QDDYQLVRKL GRGKYSEVFE AINITNNERV VVKILKPVKK KKIKREVKIL ENLRGGTNII KLIDTVKDPV SKTPALVFEY INNTDFKQLY QILTDFDIRF YMYELLKALD YCHSKGIMHR DVKPHNVMID HQQKKLRLID WGLAEFYHPA QEYNVRVASR YFKGPELLVD YQMYDYSLDM WSLGCMLASM IFRREPFFHG QDNYDQLVRI AKVLGTEELY GYLKKYHIDL DPHFNDILGQ HSRKRWENFI HSENRHLVSP EALDLLDKLL RYDHQQRLTA KEAMEHPYFY PVVKEQSQPC ADNAVLSSGL TAAR

Casein kinase 2 subunit alpha (CSNK2A2) controls numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. CSNK2A2 protein functions as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response.

CSNK2A2 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 374 amino acids (1-350 a.a) andhaving a molecular mass of 43.7kDa.CSNK2A2 is fused to a 24 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:CK2A2: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
UniProt Protein Details:

Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; CK2 family

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: PcG protein complex; nucleus; cytosol

Molecular Function:protein serine/threonine kinase activity; protein binding; protein N-terminus binding; ATP binding

Biological Process: axon guidance; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; mitotic cell cycle; protein amino acid phosphorylation

NCBI Summary:This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]
UniProt Code:P19784
NCBI GenInfo Identifier:125266
NCBI Gene ID:1459
NCBI Accession:P19784.1
UniProt Related Accession:P19784
Molecular Weight:
NCBI Full Name:Casein kinase II subunit alpha'
NCBI Synonym Full Names:casein kinase 2 alpha 2
NCBI Official Symbol:CSNK2A2  
NCBI Official Synonym Symbols:CK2A2; CSNK2A1; CK2alpha'  
NCBI Protein Information:casein kinase II subunit alpha'
UniProt Protein Name:Casein kinase II subunit alpha'
Protein Family:Protein
UniProt Gene Name:CSNK2A2  
UniProt Entry Name:CSK22_HUMAN
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