Human CSF2RB Recombinant Protein (RPPB0138)

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SKU:
RPPB0138
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CSF2RB
Synonyms:
CSF2RB
Synonyms:
ColonyStimulating Factor 2 Receptor
Synonyms:
Beta
Synonyms:
Low-Affinity (Granulocyte-Macrophage)
Source:
Sf9 Insect cells
Uniprot:
P32927
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Description

Product Name:Human CSF2RB Recombinant Protein
Product Code:RPPB0138
Size:10µg
Species:Human
Target:CSF2RB
Synonyms:CSF2RB,ColonyStimulating Factor 2 Receptor, Beta, Low-Affinity (Granulocyte-Macrophage), GM-CSF/IL-3/IL-5Receptor Common Beta Subunit, CDw131, IL3RB, SMDP5, IL5RB, Interleukin 3Receptor/Granulocyte-Macrophage Colony Stimulating Factor 3 Receptor, Beta(High Affinity), Colony-Stimulating Factor-2 Receptor, Beta, Low-Affinity,GM-CSF/IL-3/IL-5 Receptor Common Beta-Chain, Cytokine Receptor CommonSubunit Beta, CD131 Antigen, CD131.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:CSF2RB protein solution (0.5mg/ml)containing Phosphate Buffered Saline(pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:WERSLAGAEE TIPLQTLRCY NDYTSHITCR WADTQDAQRL VNVTLIRRVNEDLLEPVSCD LSDDMPWSAC PHPRCVPRRC VIPCQSFVVT DVDYFSFQPD RPLGTRLTVT LTQHVQPPEPRDLQISTDQD HFLLTWSVAL GSPQSHWLSP GDLEFEVVYK RLQDSWEDAA ILLSNTSQAT LGPEHLMPSS TYVARVRTRL APGSRLSGRP SKWSPEVCWD SQPGDEAQPQNLECFFDGAA VLSCSWEVRK EVASSVSFGL FYKPSPDAGE EECSPVLREG LGSLHTRHHC QIPVPDPATHGQYIVSVQPR RAEKHIKSSV NIQMAPPSLN VTKDGDSYSL RWETMKMRYE HIDHTFEIQY RKDTATWKDS KTETLQNAHSMALPALEPST RYWARVRVRT SRTGYNGIWS EWSEARSWDT ESVLPMWLEH HHHHH

GM-CSF Receptor Beta, also known as CSF2RB is a member of the type I cytokine receptor family. CSF2RB is a high affinity receptor for interleukin-3, interleukin-5 as well as granulocyte-macrophage colony-stimulating factor. CSF2RB unique form of receptor assembly applies also to IL-3 and IL-5 receptors, providing a structural basis for understanding their activation mechanism which is essential for the development of therapeutics.

CSF2RB Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 435 amino acids (17-443 a.a) and having a molecular mass of 49.7kDa. (Migrates at 40-57kDa on SDS-PAGE under reducing conditions). CSF2RB is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CSF2RB: a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: granulocyte macrophage colony-stimulating factor receptor complex; plasma membrane

Molecular Function:interleukin-3 receptor activity; interleukin-5 receptor activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity

Biological Process: cellular protein metabolic process; MAPKKK cascade; respiratory gaseous exchange

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 5

NCBI Summary:The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]
UniProt Code:P32927
NCBI GenInfo Identifier:1345923
NCBI Gene ID:1439
NCBI Accession:P32927.2
UniProt Secondary Accession:P32927,Q5JZI1, Q6ICE0,
UniProt Related Accession:P32927
Molecular Weight:97,976 Da
NCBI Full Name:Cytokine receptor common subunit beta
NCBI Synonym Full Names:colony stimulating factor 2 receptor beta common subunit
NCBI Official Symbol:CSF2RB  
NCBI Official Synonym Symbols:CD131; IL3RB; IL5RB; SMDP5; CDw131  
NCBI Protein Information:cytokine receptor common subunit beta
UniProt Protein Name:Cytokine receptor common subunit beta
UniProt Synonym Protein Names:CDw131; GM-CSF/IL-3/IL-5 receptor common beta subunit; CD_antigen: CD131
Protein Family:Cytokine receptor
UniProt Gene Name:CSF2RB  
UniProt Entry Name:IL3RB_HUMAN
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