Human CREG1 Recombinant Protein (RPPB3250)
- SKU:
- RPPB3250
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- CREG1
- Synonyms:
- Cellular repressor of E1A-stimulated genes 1
- protein CREG1
- CREG
- Source:
- Escherichia Coli
- Uniprot:
- O75629
Description
| Product Name: | Human CREG1 Recombinant Protein |
| Product Code: | RPPB3250 |
| Size: | 20µg |
| Species: | Human |
| Target: | CREG1 |
| Synonyms: | Cellular repressor of E1A-stimulated genes 1, protein CREG1, CREG. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CREG1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMRGGRDH GDWDEASRLP PLPPREDAAR VARFVTHVSD WGALATISTL EAVRGRPFAD VLSLSDGPPG AGSGVPYFYL SPLQLSVSNL QENPYATLTM TLAQTNFCKK HGFDPQSPLC VHIMLSGTVT KVNETEMDIA KHSLFIRHPE MKTWPSSHNW FFAKLNITNI WVLDYFGGPK IVTPEEYYNV TVQ |
Cellular Repressor of E1A-Stimulated Genes 1 (CREG1) both activates and inhibits gene expression to stimulate cellular proliferation and hinder differentiation. CREG1 antagonizes transcriptional activation and cellular transformation by E1A. CREG1 shares partial sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. CREG1 contributes to the transcriptional control of cell growth and differentiation.
CREG1 Human Recombinant produced in E. coli is a single polypeptide chain containing 213 amino acids (32-220) and having a molecular mass of 23.6 kDa.CREG1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CREG1: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. Belongs to the CREG family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Transcription, coactivator/corepressor; Secreted Chromosomal Location of Human Ortholog: 1q24 Cellular Component: extracellular space Molecular Function:transcription corepressor activity Biological Process: cell proliferation; multicellular organismal development; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75629 |
| NCBI GenInfo Identifier: | 59797902 |
| NCBI Gene ID: | 8804 |
| NCBI Accession: | O75629.1 |
| UniProt Secondary Accession: | O75629,Q8N9A3, B2RDD4, |
| UniProt Related Accession: | O75629 |
| Molecular Weight: | 24,075 Da |
| NCBI Full Name: | Protein CREG1 |
| NCBI Synonym Full Names: | cellular repressor of E1A stimulated genes 1 |
| NCBI Official Symbol: | CREG1 |
| NCBI Official Synonym Symbols: | CREG |
| NCBI Protein Information: | protein CREG1 |
| UniProt Protein Name: | Protein CREG1 |
| UniProt Synonym Protein Names: | Cellular repressor of E1A-stimulated genes 1 |
| Protein Family: | Protein |
| UniProt Gene Name: | CREG1 |
| UniProt Entry Name: | CREG1_HUMAN |
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