Human CRCP Recombinant Protein (RPPB3247)
- SKU:
- RPPB3247
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- CRCP
- Synonyms:
- CGRP receptor component protein
- CGRP-RCP
- RCP
- RCP9
- Source:
- Escherichia Coli
- Uniprot:
- O75575
Description
| Product Name: | Human CRCP Recombinant Protein |
| Product Code: | RPPB3247 |
| Size: | 20µg |
| Species: | Human |
| Target: | CRCP |
| Synonyms: | CGRP receptor component protein, CGRP-RCP, RCP, RCP9, Calcitonin gene-related peptide-receptor component protein, RNA polymerase III subunit C9, DNA-directed RNA polymerase III subunit RPC9, HsC17, MGC111194. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CRCP solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MEVKDANSAL LSNYEVFQLL TDLKEQRKES GKNKHSSGQQ NLNTITYETL KYISKTPCRH QSPEIVREFL TALKSHKLTK AEKLQLLNHR PVTAVEIQLM VEESEERLTE EQIEALLHTV TSILPAEPEA EQKKNTNSNV AMDEEDPA |
CRCP is a ubiquitous coupling protein for the calcitonin gene-related peptide and adrenomedullin receptors. CRCP controls ligand sensitivity in several tissues and has DNA-directed RNA polymerase activity, catalytic activity and calcitonin receptor activity.
CRCP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 168 amino acids (1-148) and having a molecular mass of 19.0 kDa.The CRCP is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CGRP-RCP: an ubiquitous coupling protein for the calcitonin gene-related peptide (CGRP) and adrenomedullin receptors. Modulates ligand responsiveness in a variety of tissues. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 7q11.21 Cellular Component: nucleoplasm; DNA-directed RNA polymerase III complex; plasma membrane; acrosome; cytosol Molecular Function:calcitonin gene-related polypeptide receptor activity; DNA-directed RNA polymerase activity; nucleotide binding Biological Process: transcription from RNA polymerase III promoter; transcription initiation from RNA polymerase III promoter; termination of RNA polymerase III transcription; neuropeptide signaling pathway; positive regulation of interferon type I production; innate immune response; gene expression; defense response to virus; RNA elongation from RNA polymerase III promoter |
| NCBI Summary: | This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75575 |
| NCBI GenInfo Identifier: | 20532033 |
| NCBI Gene ID: | 27297 |
| NCBI Accession: | O75575.1 |
| UniProt Secondary Accession: | O75575,Q3KRA3, Q5HYF1, Q8IXL4, A8MUZ4, A8MW23, B2R4H4 B4E198, |
| UniProt Related Accession: | O75575 |
| Molecular Weight: | 148 |
| NCBI Full Name: | DNA-directed RNA polymerase III subunit RPC9 |
| NCBI Synonym Full Names: | CGRP receptor component |
| NCBI Official Symbol: | CRCP |
| NCBI Official Synonym Symbols: | RCP; RCP9; CGRPRCP; CGRP-RCP |
| NCBI Protein Information: | DNA-directed RNA polymerase III subunit RPC9; RNA polymerase III subunit C9; CGRP-receptor component protein; calcitonin gene-related peptide-receptor component protein |
| UniProt Protein Name: | DNA-directed RNA polymerase III subunit RPC9 |
| UniProt Synonym Protein Names: | Calcitonin gene-related peptide-receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; HsC17 |
| Protein Family: | DNA-directed RNA polymerase |
| UniProt Gene Name: | CRCP |
| UniProt Entry Name: | RPC9_HUMAN |
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