Human COX5A Recombinant Protein (RPPB3236)
- SKU:
- RPPB3236
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- COX5A
- Synonyms:
- Cytochrome c oxidase subunit 5A
- mitochondrial
- Cytochrome c oxidase polypeptide Va
- COX5A
- Source:
- Escherichia Coli
- Uniprot:
- P20674
Description
| Product Name: | Human COX5A Recombinant Protein |
| Product Code: | RPPB3236 |
| Size: | 20µg |
| Species: | Human |
| Target: | COX5A |
| Synonyms: | Cytochrome c oxidase subunit 5A, mitochondrial, Cytochrome c oxidase polypeptide Va, COX5A, VA, COX, COX-VA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | COX5A protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSSHGSQET DEEFDARWVT YFNKPDIDAW ELRKGINTLV TYDMVPEPKI IDAALRACRR LNDFASTVRI LEVVKDKAGP HKEIYPYVIQ ELRPTLNELG ISTPEELGLD KV |
Cytochrome C Oxidase Subunit Va (COX5A) is a member of the cytochrome c oxidase subunit 5A family. COX (Cytochrome C Oxidase), which is the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced Cytochrome C to oxygen. The COX component is a heteromeric complex comprised of three catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits serve in electron transfer, and the nuclear-encoded subunits act in the regulation and assembly of the complex. COX5A is the heme A-containing chain of Cytochrome C Oxidase,which is the terminal oxidase in mitochondrial electron transport.
COX5A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 132 amino acids (42-150 a.a) and having a molecular mass of 14.9kDa.COX5A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | COX5A: This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase subunit 5A family. |
| UniProt Protein Details: | Protein type:EC 1.9.3.1; Oxidoreductase; Energy Metabolism - oxidative phosphorylation; Mitochondrial Chromosomal Location of Human Ortholog: 15q24.1 Cellular Component: mitochondrial inner membrane Molecular Function:cytochrome-c oxidase activity; electron carrier activity; metal ion binding Biological Process: cellular metabolic process; transmembrane transport |
| NCBI Summary: | Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20674 |
| NCBI GenInfo Identifier: | 218511986 |
| NCBI Gene ID: | 9377 |
| NCBI Accession: | P20674.2 |
| UniProt Secondary Accession: | P20674,P30045, Q8TB65, |
| UniProt Related Accession: | P20674 |
| Molecular Weight: | 150 |
| NCBI Full Name: | Cytochrome c oxidase subunit 5A, mitochondrial |
| NCBI Synonym Full Names: | cytochrome c oxidase subunit Va |
| NCBI Official Symbol: | COX5A |
| NCBI Official Synonym Symbols: | VA; COX; COX-VA |
| NCBI Protein Information: | cytochrome c oxidase subunit 5A, mitochondrial; cytochrome c oxidase polypeptide Va; mitochondrial cytochrome c oxidase subunit Va; cytochrome c oxidase polypeptide, mitochondrial |
| UniProt Protein Name: | Cytochrome c oxidase subunit 5A, mitochondrial |
| UniProt Synonym Protein Names: | Cytochrome c oxidase polypeptide Va |
| Protein Family: | Cytochrome c oxidase |
| UniProt Gene Name: | COX5A |
| UniProt Entry Name: | COX5A_HUMAN |
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