Human COTL1 Recombinant Protein (RPPB3234)
- SKU:
- RPPB3234
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- COTL1
- Synonyms:
- Coactosin-like protein
- COTL1
- CLP
- FLJ43657
- Source:
- Escherichia Coli
- Uniprot:
- Q14019
Description
| Product Name: | Human COTL1 Recombinant Protein |
| Product Code: | RPPB3234 |
| Size: | 20µg |
| Species: | Human |
| Target: | COTL1 |
| Synonyms: | Coactosin-like protein, COTL1, CLP, FLJ43657, MGC19733. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The COTL1 solution (1 mg/ml) 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 1mM DTT and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MATKIDKEAC RAAYNLVRDD GSAVIWVTFK YDGSTIVPGE QGAEYQHFIQ QCTDDVRLFA FVRFTTGDAM SKRSKFALIT WIGENVSGLQ RAKTGTDKTL VKEVVQNFAK EFVISDRKEL EEDFIKSELK KAGGANYDAQ TE |
Coactosin-like protein (COTL1) is one of the numerous actin-binding proteins which regulate the actin cytoskeleton. COTL1 binds F-actin, it also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. COTL1 binds to F-actin in a calcium-independent way and has no direct effect on actin depolymerization.
COTL1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 162 amino acids (1-142 a.a.) and having a molecular mass of 18.1kDa. The COTL1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | COTL1: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Belongs to the actin-binding proteins ADF family. Coactosin subfamily. |
| UniProt Protein Details: | Protein type:Actin-binding Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: nuclear membrane; cytoskeleton; cytoplasm Molecular Function:protein binding; enzyme binding; actin binding Biological Process: defense response to fungus |
| NCBI Summary: | This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14019 |
| NCBI GenInfo Identifier: | 21759076 |
| NCBI Gene ID: | 23406 |
| NCBI Accession: | Q14019.3 |
| UniProt Related Accession: | Q14019 |
| Molecular Weight: | |
| NCBI Full Name: | Coactosin-like protein |
| NCBI Synonym Full Names: | coactosin like F-actin binding protein 1 |
| NCBI Official Symbol: | COTL1 |
| NCBI Official Synonym Symbols: | CLP |
| NCBI Protein Information: | coactosin-like protein |
| UniProt Protein Name: | Coactosin-like protein |
| Protein Family: | Coactosin-like protein |
| UniProt Gene Name: | COTL1 |
| UniProt Entry Name: | COTL1_HUMAN |
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