Human CNTFR Recombinant Protein (RPPB0133)
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주문- SKU:
- RPPB0133
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- CNTFR
- Synonyms:
- CiliaryNeurotrophic Factor Receptor
- Synonyms:
- CNTF Receptor Subunit Alpha
- Synonyms:
- CNTFR-Alpha
- Synonyms:
- CiliaryNeurotrophic Factor Receptor Subunit Alpha
- Source:
- Escherichia Coli
- Uniprot:
- P26992
Description
| Product Name: | Human CNTFR Recombinant Protein |
| Product Code: | RPPB0133 |
| Size: | 25µg |
| Species: | Human |
| Target: | CNTFR |
| Synonyms: | CiliaryNeurotrophic Factor Receptor, CNTF Receptor Subunit Alpha, CNTFR-Alpha, CiliaryNeurotrophic Factor Receptor Subunit Alpha, Ciliary neurotrophic factorreceptor subunit alpha, CNTF receptor subunit alpha, CNTFR-alpha. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless clear solution. |
| Formulation: | CNTFR protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MQRHSPQEAP HVQYERLGSD VTLPCGTANW DAAVTWRVNG TDLAPDLLNG SQLVLHGLELGHSGLYACFH RDSWHLRHQV LLHVGLPPRE PVLSCRSNTY PKGFYCSWHL PTPTYIPNTF NVTVLHGSKIMVCEKDPALK NRCHIRYMHL FSTIKYKVSI SVSNALGHNA TAITFDEFTI VKPDPPENVV ARPVPSNPRRLEVTWQTPST WPDPESFPLK FFLRYRPLIL DQWQHVELSD GTAHTITDAY AGKEYIIQVA AKDNEIGTWSDWSVAAHATP WTEEPRHLTT EAQAAETTTS TTSSLAPPPT TKICDPGELG S |
Ciliary Neurotrophic Factor Receptor, also known as CNTFR is a member ofthe type I cytokine receptor family. CNTFR binds to CNTF. The alpha subunitprovides the receptor specificity. Solenucleotide polymorphisms in CNTFR has been associated with variations in musclestrength, in addition to early onset of eating disorders.
CNTFR Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 341 amino acids (23-342 a.a) andhaving a molecular mass of 38.1kDa.CNTFR is fused to a 21 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CNTFR: Binds to CNTF. The alpha subunit provides the receptor specificity. Belongs to the type I cytokine receptor family. Type 3 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Receptor, misc. Chromosomal Location of Human Ortholog: 9p13 Cellular Component: extrinsic to membrane Molecular Function:cytokine binding; ciliary neurotrophic factor receptor activity; receptor binding Biological Process: nervous system development; suckling behavior; positive regulation of cell proliferation; negative regulation of neuron apoptosis; signal transduction; sex differentiation |
| NCBI Summary: | This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011] |
| UniProt Code: | P26992 |
| NCBI GenInfo Identifier: | 1352099 |
| NCBI Gene ID: | 1271 |
| NCBI Accession: | P26992.2 |
| UniProt Related Accession: | P26992 |
| Molecular Weight: | 40kDa |
| NCBI Full Name: | Ciliary neurotrophic factor receptor subunit alpha |
| NCBI Synonym Full Names: | ciliary neurotrophic factor receptor |
| NCBI Official Symbol: | CNTFR |
| NCBI Protein Information: | ciliary neurotrophic factor receptor subunit alpha |
| UniProt Protein Name: | Ciliary neurotrophic factor receptor subunit alpha |
| Protein Family: | Ciliary neurotrophic factor receptor |
| UniProt Gene Name: | CNTFR |
| UniProt Entry Name: | CNTFR_HUMAN |
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