Human CNPY3 Recombinant Protein (RPPB3217)

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SKU:
RPPB3217
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CNPY3
Synonyms:
CAG4A
Synonyms:
ERDA5
Synonyms:
PRAT4A
Synonyms:
TNRC5
Source:
Escherichia Coli
Uniprot:
Q9BT09
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Description

Product Name:Human CNPY3 Recombinant Protein
Product Code:RPPB3217
Size:20µg
Species:Human
Target:CNPY3
Synonyms:CAG4A, ERDA5, PRAT4A, TNRC5, Protein canopy homolog 3, CTG repeat protein 4a, Expanded repeat-domain protein CAG/CTG 5, Protein associated with TLR4, Trinucleotide repeat-containing gene 5 protein,CNPY3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CNPY3 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSGPSQAGA EENDWVRLPS KCEVCKYVAV ELKSAFEETG KTKEVIGTGY GILDQKASGV KYTKSDLRLI EVTETICKRL LDYSLHKERT GSNRFAKGMS ETFETLHNLV HKGVKVVMDI PYELWNETSA EVADLKKQCD VLVEEFEEVI EDWYRNHQEE DLTEFLCANH VLKGKDTSCL AEQWSGKKGD TAALGGKKSK KKSSRAKAAG GRSSSSKQRK ELGGLEGDPS PEEDEGIQKA SPLTHSPPDE L

Canopy 3 homolog (CNPY3) is a 271 a.aToll-like receptor specific co-chaperone for HSP90B1. CNPY3 is necessitated for proper TLR folding, excluding that of TLR3, and so controls TLR exit from the endoplasmic reticulum. Therefore, CNPY3i s required for both innate and adaptive immune responses.

CNPY3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 271 amino acids (31-278 a.a.) and having a molecular mass of 29.9kDa. CNPY3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TNRC5: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptative immune responses. Belongs to the canopy family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: endoplasmic reticulum lumen

Molecular Function:receptor binding

Biological Process: toll-like receptor signaling pathway; innate immune response

NCBI Summary:This gene encodes a protein that binds members of the toll-like receptor protein family and functions as a chaperone to aid in folding and export of these proteins. Alternative splicing results in multiple transcript variants. Naturally occuring readthrough transcription occurs between this locus and the downstream GNMT (glycine N-methyltransferase) gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]
UniProt Code:Q9BT09
NCBI GenInfo Identifier:74752319
NCBI Gene ID:10695
NCBI Accession:Q9BT09.1
UniProt Related Accession:Q9BT09
Molecular Weight:
NCBI Full Name:Protein canopy homolog 3
NCBI Synonym Full Names:canopy FGF signaling regulator 3
NCBI Official Symbol:CNPY3  
NCBI Official Synonym Symbols:CAG4A; ERDA5; TNRC5; EIEE60; PRAT4A  
NCBI Protein Information:protein canopy homolog 3
UniProt Protein Name:Protein canopy homolog 3
UniProt Synonym Protein Names:CTG repeat protein 4a; Expanded repeat-domain protein CAG/CTG 5; Protein associated with TLR4; Trinucleotide repeat-containing gene 5 protein
Protein Family:Protein canopy
UniProt Gene Name:CNPY3  
UniProt Entry Name:CNPY3_HUMAN
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