Human CNOT8 Recombinant Protein (RPPB3219)

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주문
SKU:
RPPB3219
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CNOT8
Synonyms:
CCR4-NOT transcription complex subunit 8
Synonyms:
CAF1
Synonyms:
CALIF
Synonyms:
hCAF1
Source:
Escherichia Coli
Uniprot:
Q9UFF9
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Description

Product Name:Human CNOT8 Recombinant Protein
Product Code:RPPB3219
Size:20µg
Species:Human
Target:CNOT8
Synonyms:CCR4-NOT transcription complex subunit 8, CAF1, CALIF, hCAF1, POP2, CAF1-like protein, CAF2, CCR4-associated factor 8, Caf1b, CNOT8.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CNOT8 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPAALVE NSQVICEVWA SNLEEEMRKI REIVLSYSYI AMDTEFPGVV VRPIGEFRSS IDYQYQLLRC NVDLLKIIQL GLTFTNEKGE YPSGINTWQF NFKFNLTEDM YSQDSIDLLA NSGLQFQKHE EEGIDTLHFA ELLMTSGVVL CDNVKWLSFH SGYDFGYMVK LLTDSRLPEE EHEFFHILNL FFPSIYDVKY LMKSCKNLKG GLQEVADQLD LQRIGRQHQA GSDSLLTGMA FFRMKELFFE DSIDDAKYCG RLYGLGTGVA QKQNEDVDSA QEKMSILAII NNMQQ

CCR4-NOT Transcription Complex, Subunit 8 (CNOT8) is a part of the CAF1 family. CNOT8 is a ubiquitous transcription factor necessary for a varied set of processes and functions as part of the CCR-NOT complex. The CCR4-NOT complex which functions as general transcription regulation complex binds BTG2 and holds CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8

CNOT8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (1-292) and having a molecular mass of 35.9 kDa.CNOT8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CNOT8: Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex. Belongs to the CAF1 family.
UniProt Protein Details:

Protein type:EC 3.1.13.4

Chromosomal Location of Human Ortholog: 5q31-q33

Cellular Component: intracellular; cytosol; nucleus; CCR4-NOT complex

Molecular Function:protein binding; 3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; RNA binding; metal ion binding; transcription factor activity

Biological Process: regulation of translation; negative regulation of cell proliferation; poly(A) tail shortening; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; gene expression; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay

UniProt Code:Q9UFF9
NCBI GenInfo Identifier:15213949
NCBI Gene ID:9337
NCBI Accession:Q9UFF9.1
UniProt Secondary Accession:Q9UFF9,O95709, Q7Z521, Q9H6Y1, B0AZS3, B2RAR8, B7Z8R1 D3DQI8,
UniProt Related Accession:Q9UFF9
Molecular Weight:27,415 Da
NCBI Full Name:CCR4-NOT transcription complex subunit 8
NCBI Synonym Full Names:CCR4-NOT transcription complex, subunit 8
NCBI Official Symbol:CNOT8  
NCBI Official Synonym Symbols:CAF1; POP2; CALIF; Caf1b; hCAF1  
NCBI Protein Information:CCR4-NOT transcription complex subunit 8; CAF2; CALIFp; CAF1-like protein; CCR4-associated factor 8; PGK promoter directed over production
UniProt Protein Name:CCR4-NOT transcription complex subunit 8
UniProt Synonym Protein Names:CAF1-like protein; CALIFp; CAF2; CCR4-associated factor 8; Caf1b
Protein Family:CCR4-NOT transcription complex
UniProt Gene Name:CNOT8  
UniProt Entry Name:CNOT8_HUMAN
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