Human CLPP Recombinant Protein (RPPB1496)
- SKU:
- RPPB1496
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- CLPP
- Synonyms:
- Putative ATP-dependent Clp protease proteolytic subunit mitochondrial
- Endopeptidase Clp
- CLPP
- Source:
- Escherichia Coli
- Uniprot:
- Q16740
Frequently bought together:
Description
| Product Name: | Human CLPP Recombinant Protein |
| Product Code: | RPPB1496 |
| Size: | 10µg |
| Species: | Human |
| Target: | CLPP |
| Synonyms: | Putative ATP-dependent Clp protease proteolytic subunit mitochondrial, Endopeptidase Clp, CLPP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CLPP solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 7.5), 2mM DTT, 20% glycerol and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MPLIPIVVEQ TGRGERAYDI YSRLLRERIV CVMGPIDDSV ASLVIAQLLF LQSESNKKPI HMYINSPGGV VTAGLAIYDT MQYILNPICT WCVGQAASMG SLLLAAGTPG MRHSLPNSRI MIHQPSGGAR GQATDIAIQA EEIMKLKKQL YNIYAKHTKQ SLQVIESAME RDRYMSPMEA QEFGILDKVL VHPPQDGEDE PTLVQKEPVE AAPAAEPVPA ST |
ATP-dependent Clp protease proteolytic subunit (CLPP) is a member of the peptidase family S14. CLPP cleaves peptides in a variety of proteins in a manner which requires ATP hydrolysis. CLPP being the catalytic core of the Clp proteolytic complex is commonly involved in many cellular processes via the regulation of intracellular protein quality. CLPP is responsible for a somewhat general and central housekeeping function rather than for the degradation of specific substrates.
CLPP produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids (57-277 a.a.) and having a molecular mass of 24.2kDa.CLPP is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. |
| NCBI Summary: | The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16740 |
| NCBI GenInfo Identifier: | 5174419 |
| NCBI Gene ID: | 8192 |
| NCBI Accession: | NP_006003 |
| UniProt Secondary Accession: | Q16740,B2R4W5, |
| UniProt Related Accession: | Q16740 |
| Molecular Weight: | 24.2kDa (222aa), confirmed by MALDI-TOF |
| NCBI Full Name: | ATP-dependent Clp protease proteolytic subunit, mitochondrial |
| NCBI Synonym Full Names: | caseinolytic mitochondrial matrix peptidase proteolytic subunit |
| NCBI Official Symbol: | CLPP |
| NCBI Official Synonym Symbols: | DFNB81; PRLTS3 |
| NCBI Protein Information: | ATP-dependent Clp protease proteolytic subunit, mitochondrial |
| UniProt Protein Name: | ATP-dependent Clp protease proteolytic subunit, mitochondrial |
| UniProt Synonym Protein Names: | Endopeptidase Clp |
| Protein Family: | ATP-dependent Clp protease proteolytic |
| UniProt Gene Name: | CLPP |
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