Human CLPP Recombinant Protein (RPPB1496)

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SKU:
RPPB1496
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CLPP
Synonyms:
Putative ATP-dependent Clp protease proteolytic subunit mitochondrial
Synonyms:
Endopeptidase Clp
Synonyms:
CLPP
Source:
Escherichia Coli
Uniprot:
Q16740
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Description

Product Name:Human CLPP Recombinant Protein
Product Code:RPPB1496
Size:10µg
Species:Human
Target:CLPP
Synonyms:Putative ATP-dependent Clp protease proteolytic subunit mitochondrial, Endopeptidase Clp, CLPP.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:CLPP solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 7.5), 2mM DTT, 20% glycerol and 100mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MPLIPIVVEQ TGRGERAYDI YSRLLRERIV CVMGPIDDSV ASLVIAQLLF LQSESNKKPI HMYINSPGGV VTAGLAIYDT MQYILNPICT WCVGQAASMG SLLLAAGTPG MRHSLPNSRI MIHQPSGGAR GQATDIAIQA EEIMKLKKQL YNIYAKHTKQ SLQVIESAME RDRYMSPMEA QEFGILDKVL VHPPQDGEDE PTLVQKEPVE AAPAAEPVPA ST

ATP-dependent Clp protease proteolytic subunit (CLPP) is a member of the peptidase family S14. CLPP cleaves peptides in a variety of proteins in a manner which requires ATP hydrolysis. CLPP being the catalytic core of the Clp proteolytic complex is commonly involved in many cellular processes via the regulation of intracellular protein quality. CLPP is responsible for a somewhat general and central housekeeping function rather than for the degradation of specific substrates.

CLPP produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids (57-277 a.a.) and having a molecular mass of 24.2kDa.CLPP is purified by proprietary chromatographic techniques.

UniProt Protein Function:Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
NCBI Summary:The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
UniProt Code:Q16740
NCBI GenInfo Identifier:5174419
NCBI Gene ID:8192
NCBI Accession:NP_006003
UniProt Secondary Accession:Q16740,B2R4W5,
UniProt Related Accession:Q16740
Molecular Weight:24.2kDa (222aa), confirmed by MALDI-TOF
NCBI Full Name:ATP-dependent Clp protease proteolytic subunit, mitochondrial
NCBI Synonym Full Names:caseinolytic mitochondrial matrix peptidase proteolytic subunit
NCBI Official Symbol:CLPP  
NCBI Official Synonym Symbols:DFNB81; PRLTS3  
NCBI Protein Information:ATP-dependent Clp protease proteolytic subunit, mitochondrial
UniProt Protein Name:ATP-dependent Clp protease proteolytic subunit, mitochondrial
UniProt Synonym Protein Names:Endopeptidase Clp
Protein Family:ATP-dependent Clp protease proteolytic
UniProt Gene Name:CLPP  
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