Human CLEC5A Recombinant Protein (RPPB3199)
- SKU:
- RPPB3199
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- CLEC5A
- Synonyms:
- C-type lectin domain family 5 member A
- CLECSF5
- MDL-1
- MDL1
- Source:
- Sf9 Insect cells
- Uniprot:
- Q9NY25
Description
| Product Name: | Human CLEC5A Recombinant Protein |
| Product Code: | RPPB3199 |
| Size: | 5µg |
| Species: | Human |
| Target: | CLEC5A |
| Synonyms: | C-type lectin domain family 5 member A , CLECSF5, MDL-1,MDL1, C-type lectin superfamily member 5, Myeloid DAP12-associating lectin 1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CLEC5A protein solution (0.25mg/ml) contains 20% glycerol, 1mM DTT & Phosphate buffered saline (pH7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLPQIFNKS NDGFTTTRSY GTVSQIFGSS SPSPNGFITT RSYGTVCPKD WEFYQARCFF LSTSESSWNE SRDFCKGKGS TLAIVNTPEK LKFLQDITDA EKYFIGLIYH REEKRWRWIN NSVFNGNVTN QNQNFNCATI GLTKTFDAAS CDISYRRICE KNAKHHHHHH |
C-type lectin domain family 5-member A isoform 1 (CLEC5A) is part of the CTL/CTLD superfamily which carry various functions, for instance cell-cell signaling, cell adhesion, glycoprotein turnover, in addition to their inflammation & immune response abilities. CLEC5A operates as a cell attachment receptor for all 4 serotypes of Dengue virus in addition to Japanese encephalitis virus. CLEC5A binds to the dengue virus and it triggers signaling through the phosphylation of TYROBP, as a result no viral entrance occurs, however this interaction does stimulate proinflammatory cytokine release. CLEC5A preforms as a positive regulator of osteoclastogenesis and also a main regulator of synovial injury & bone erosion for the period of autoimmune joint inflammation.
CLEC5A produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (28-188 a.a.) and fused to a 9 aa His Tag at C-terminus containing a total of 170 amino acids and having a molecular mass of 19.5kDa.CLEC5A shows multiple bands between 28-40kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Code: | Q9NY25 |
| NCBI GenInfo Identifier: | 59797971 |
| NCBI Gene ID: | 23601 |
| NCBI Accession: | Q9NY25.1 |
| UniProt Secondary Accession: | Q9NY25,Q9R007, |
| UniProt Related Accession: | Q9NY25 |
| Molecular Weight: | 188 |
| NCBI Full Name: | C-type lectin domain family 5 member A |
| NCBI Synonym Full Names: | C-type lectin domain family 5, member A |
| NCBI Official Symbol: | CLEC5A |
| NCBI Official Synonym Symbols: | MDL1; MDL-1; CLECSF5 |
| NCBI Protein Information: | C-type lectin domain family 5 member A; C-type lectin superfamily member 5; myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5 |
| UniProt Protein Name: | C-type lectin domain family 5 member A |
| UniProt Synonym Protein Names: | C-type lectin superfamily member 5; Myeloid DAP12-associating lectin 1; MDL-1 |
| UniProt Gene Name: | CLEC5A |
| UniProt Entry Name: | CLC5A_HUMAN |
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