Human CLEC4E Recombinant Protein (RPPB3197)

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SKU:
RPPB3197
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CLEC4E
Synonyms:
C-TypeLectin Domain Family 4
Synonyms:
Member E
Synonyms:
MINCLE
Synonyms:
C-Type (Calcium Dependent
Source:
Escherichia Coli
Uniprot:
Q9ULY5
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Description

Product Name:Human CLEC4E Recombinant Protein
Product Code:RPPB3197
Size:20µg
Species:Human
Target:CLEC4E
Synonyms:C-TypeLectin Domain Family 4, Member E, MINCLE, C-Type (Calcium Dependent,Carbohydrate-Recognition Domain) Lectin, Superfamily Member 9, Macrophage-InducibleC-Type Lectin, C-Type Lectin Superfamily Member 9, CLECSF9, C-Type LectinDomain Family 4 Member E, C-type lectin domain family 4 member E.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CLEC4Eprotein solution (0.25mg/ml) containing 20mM Tris 8.0 and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MRCVVTFRIFQTCDEKKFQL PENFTELSCY NYGSGSVKNC CPLNWEYFQS SCYFFSTDTI SWALSLKNCS AMGAHLVVINSQEEQEFLSY KKPKMREFFI GLSDQVVEGQ WQWVDGTPLT KSLSFWDVGE PNNIATLEDC ATMRDSSNPRQNWNDVTCFL NYFRICEMVG INPLNKGKSL

C-type lectin domain family 4, member E, also known as CLEC4E is a C-type lectin receptor expressed through a wide range of antigens which presents cells including macrophages, neutrophils, dendritic cells as well as B cells; Furthermore, a variety of stimuli including stress are acknowledged to induce the expression of CLEC4E.

CLEC4E Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 200 amino acids (41-219 a.a) and having amolecular mass of 22.9kDa.CLEC4E is fused to a 21 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:CLEC4E: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function:carbohydrate binding; receptor activity

Biological Process: defense response to bacterium; innate immune response; positive regulation of cytokine secretion; stimulatory C-type lectin receptor signaling pathway; T cell differentiation during immune response

NCBI Summary:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
UniProt Code:Q9ULY5
NCBI GenInfo Identifier:7657333
NCBI Gene ID:26253
NCBI Accession:NP_055173.1
UniProt Secondary Accession:Q9ULY5,B2R6Q6,
UniProt Related Accession:Q9ULY5
Molecular Weight:25,073 Da
NCBI Full Name:C-type lectin domain family 4 member E
NCBI Synonym Full Names:C-type lectin domain family 4 member E
NCBI Official Symbol:CLEC4E  
NCBI Official Synonym Symbols:MINCLE; CLECSF9  
NCBI Protein Information:C-type lectin domain family 4 member E
UniProt Protein Name:C-type lectin domain family 4 member E
UniProt Synonym Protein Names:C-type lectin superfamily member 9; Macrophage-inducible C-type lectin
Protein Family:C-type lectin domain family
UniProt Gene Name:CLEC4E  
UniProt Entry Name:CLC4E_HUMAN
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