Human CLEC2D Recombinant Protein (RPPB3196)

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SKU:
RPPB3196
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CLEC2D
Synonyms:
C-type lectin domain family 2 member D
Synonyms:
CLAX1
Synonyms:
LLT11
Synonyms:
OCIL
Source:
Escherichia Coli
Uniprot:
Q9UHP7
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Description

Product Name:Human CLEC2D Recombinant Protein
Product Code:RPPB3196
Size:20µg
Species:Human
Target:CLEC2D
Synonyms:C-type lectin domain family 2 member D, CLAX1, LLT11, OCIL.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CLEC2D solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSRANCHQE PSVCLQAACP ESWIGFQRKC FYFSDDTKNW TSSQRFCDSQ DADLAQVESF QELNFLLRYK GPSDHWIGLS REQGQPWKWI NGTEWTRQFP ILGAGECAYL NDKGASSARH YTERKWICSK SDIHV

C-type lectin domain family 2, also referred to CLEC2D, is a receptor for KLRB1 which protects target cells against natural killer cell-mediated lysis.It has been shown that CLEC2Dinhibits osteoclast formation and bone resorption. The protein controls the release of interferon-gamma and contains a transmembrane domain near the N-terminus likewisethe C-type lectin-like extracellular domain.

CLEC2D Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids (60-191 a.a.) and having a molecular mass of 17.7 kDa. CLEC2D is fused to a 23 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CLEC2D: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cell surface; membrane; endoplasmic reticulum; integral to plasma membrane

Molecular Function:transmembrane receptor activity; carbohydrate binding

Biological Process: cell surface receptor linked signal transduction

NCBI Summary:This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010]
UniProt Code:Q9UHP7
NCBI GenInfo Identifier:74753331
NCBI Gene ID:29121
NCBI Accession:Q9UHP7.1
UniProt Secondary Accession:Q9UHP7,Q6YID5, Q8WUP7, Q9HD37, Q9HD38, D6CI39, D6CI40 D6CI41,
UniProt Related Accession:Q9UHP7
Molecular Weight:10,823 Da
NCBI Full Name:C-type lectin domain family 2 member D
NCBI Synonym Full Names:C-type lectin domain family 2, member D
NCBI Official Symbol:CLEC2D  
NCBI Official Synonym Symbols:CLAX; LLT1; OCIL  
NCBI Protein Information:C-type lectin domain family 2 member D; LLT-1; C-type lectin related f; lectin-like transcript 1; lectin-like NK cell receptor; osteoclast inhibitory lectin; C-type lectin superfamily 2, member D
UniProt Protein Name:C-type lectin domain family 2 member D
UniProt Synonym Protein Names:Lectin-like NK cell receptor; Lectin-like transcript 1; LLT-1; Osteoclast inhibitory lectin
Protein Family:C-type lectin domain family
UniProt Gene Name:CLEC2D  
UniProt Entry Name:CLC2D_HUMAN
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