Human CLEC2B Recombinant Protein (RPPB3194)

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SKU:
RPPB3194
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CLEC2B
Synonyms:
C-type lectin domain family 2 member B
Synonyms:
Activation-induced C-type lectin
Synonyms:
C-type lectin superfamily member 2
Synonyms:
IFN-alpha-2b-inducing-related protein 1
Source:
Escherichia Coli
Uniprot:
Q92478
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Description

Product Name:Human CLEC2B Recombinant Protein
Product Code:RPPB3194
Size:20µg
Species:Human
Target:CLEC2B
Synonyms:C-type lectin domain family 2 member B, Activation-induced C-type lectin, C-type lectin superfamily member 2, IFN-alpha-2b-inducing-related protein 1, CLEC2B, AICL, CLECSF2, IFNRG1, HP10085.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CLEC2B protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSKLTRDSQ SLCPYDWIGF QNKCYYFSKE EGDWNSSKYN CSTQHADLTI IDNIEEMNFL RRYKCSSDHW IGLKMAKNRT GQWVDGATFT KSFGMRGSEG CAYLSDDGAA TARCYTERKW ICRKRIH

C-type Lectin Domain Family 2, Member B (CLEC2B) belongs to the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of the CTL/CTLD family share a common protein fold and have various functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The CLEC2B gene is closely connected to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. CLEC2B is expressed preferentially in lymphoid tissues, and in most hematopoietic cell types.

CLEC2B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 147 amino acids (26-149 a.a) and having a molecular mass of 16.9kDa.CLEC2B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CLEC2B:
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13-p12

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: regulation of immune response

NCBI Summary:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
UniProt Code:Q92478
NCBI GenInfo Identifier:33860149
NCBI Gene ID:9976
NCBI Accession:Q92478.2
UniProt Secondary Accession:Q92478,Q8IZE9, Q9BS74, Q9UQB4, B2R9U1,
UniProt Related Accession:Q92478
Molecular Weight:17,307 Da
NCBI Full Name:C-type lectin domain family 2 member B
NCBI Synonym Full Names:C-type lectin domain family 2 member B
NCBI Official Symbol:CLEC2B  
NCBI Official Synonym Symbols:AICL; IFNRG1; CLECSF2; HP10085  
NCBI Protein Information:C-type lectin domain family 2 member B
UniProt Protein Name:C-type lectin domain family 2 member B
UniProt Synonym Protein Names:Activation-induced C-type lectin; C-type lectin superfamily member 2; IFN-alpha-2b-inducing-related protein 1
Protein Family:C-type lectin domain family
UniProt Gene Name:CLEC2B  
UniProt Entry Name:CLC2B_HUMAN
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