Human CKM Recombinant Protein (RPPB2597)

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SKU:
RPPB2597
Product type:
Recombinant Protein
Size:
1mg
Species:
Human
Target:
CKM
Synonyms:
Creatine kinase M-type
Synonyms:
EC 2732
Synonyms:
Creatine kinase M chain
Synonyms:
M-CK
Source:
Human Cardiac Tissues
Uniprot:
P06732
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Description

Product Name:Human CKM Recombinant Protein
Product Code:RPPB2597
Size:100,000U
Species:Human
Target:CKM
Synonyms:Creatine kinase M-type, EC 2.7.3.2, Creatine kinase M chain, M-CK, CKM, CKMM.
Source:Human Cardiac Tissues
Physical Appearance:Sterile Filtered clear solution.
Formulation:The CKM protein solution is in 50mM Tris and 2mM DTT, pH 7.5 containing 50% Glycerol.
Stability:CKM although stable at 14°C for 1 week, should be stored at 2°-8°C.
Purity:Greater than 50.0%.

The three isoenzymes (MM, MB, and BB) are found in muscle, cardiac and brain tissues. These recombinant proteins are ideal for calibrating diagnostic instruments and researching neuromuscular diseases. Creatine Kinases can be used for indications in many neuromuscular applications. These disorders include cardiac disease, mitochondrial disorders, inflammatory myopathies, myasthenia, polymyositis, McArdle''s disease, NMJ disorders, muscular dystrophy, ALS, hypo and hyperthyroid disorders, central core disease, acid maltase deficiency, myoglobinuria, rhabdomyolysis, motor neuron diseases, rheumatic diseases, and other that create elevated or reduced levels of Creatine Kinases.

Human CKM produced in Human Cardiac Tissues having a molecular mass of 82 kDa and PI 5.0-7.5. It’s the skeletal muscle specific creatine kinase and is elevated in case of strenuous exercise and in degenerative muscle disease.

UniProt Protein Function:CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - arginine and proline; Kinase, other; EC 2.7.3.2

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytosol

Molecular Function:creatine kinase activity; ATP binding

Biological Process: phosphocreatine biosynthetic process; phosphorylation; creatine metabolic process

NCBI Summary:The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
UniProt Code:P06732
NCBI GenInfo Identifier:125305
NCBI Gene ID:1158
NCBI Accession:P06732.2
UniProt Secondary Accession:P06732,Q96QL9,
UniProt Related Accession:P06732
Molecular Weight:Calculated: 40kDaObserved: 43kDa
NCBI Full Name:Creatine kinase M-type
NCBI Synonym Full Names:creatine kinase, muscle
NCBI Official Symbol:CKM  
NCBI Official Synonym Symbols:CKMM; M-CK  
NCBI Protein Information:creatine kinase M-type; creatine kinase M chain
UniProt Protein Name:Creatine kinase M-type
UniProt Synonym Protein Names:Creatine kinase M chain; M-CKCreatine kinase M-type, N-terminally processed
Protein Family:Creatine kinase
UniProt Gene Name:CKM  
UniProt Entry Name:KCRM_HUMAN
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