Human CKM Recombinant Protein (RPPB2597)
- SKU:
- RPPB2597
- Product type:
- Recombinant Protein
- Size:
- 1mg
- Species:
- Human
- Target:
- CKM
- Synonyms:
- Creatine kinase M-type
- EC 2732
- Creatine kinase M chain
- M-CK
- Source:
- Human Cardiac Tissues
- Uniprot:
- P06732
Description
| Product Name: | Human CKM Recombinant Protein |
| Product Code: | RPPB2597 |
| Size: | 100,000U |
| Species: | Human |
| Target: | CKM |
| Synonyms: | Creatine kinase M-type, EC 2.7.3.2, Creatine kinase M chain, M-CK, CKM, CKMM. |
| Source: | Human Cardiac Tissues |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The CKM protein solution is in 50mM Tris and 2mM DTT, pH 7.5 containing 50% Glycerol. |
| Stability: | CKM although stable at 14°C for 1 week, should be stored at 2°-8°C. |
| Purity: | Greater than 50.0%. |
The three isoenzymes (MM, MB, and BB) are found in muscle, cardiac and brain tissues. These recombinant proteins are ideal for calibrating diagnostic instruments and researching neuromuscular diseases. Creatine Kinases can be used for indications in many neuromuscular applications. These disorders include cardiac disease, mitochondrial disorders, inflammatory myopathies, myasthenia, polymyositis, McArdle''s disease, NMJ disorders, muscular dystrophy, ALS, hypo and hyperthyroid disorders, central core disease, acid maltase deficiency, myoglobinuria, rhabdomyolysis, motor neuron diseases, rheumatic diseases, and other that create elevated or reduced levels of Creatine Kinases.
Human CKM produced in Human Cardiac Tissues having a molecular mass of 82 kDa and PI 5.0-7.5. It’s the skeletal muscle specific creatine kinase and is elevated in case of strenuous exercise and in degenerative muscle disease.
| UniProt Protein Function: | CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - arginine and proline; Kinase, other; EC 2.7.3.2 Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: cytosol Molecular Function:creatine kinase activity; ATP binding Biological Process: phosphocreatine biosynthetic process; phosphorylation; creatine metabolic process |
| NCBI Summary: | The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P06732 |
| NCBI GenInfo Identifier: | 125305 |
| NCBI Gene ID: | 1158 |
| NCBI Accession: | P06732.2 |
| UniProt Secondary Accession: | P06732,Q96QL9, |
| UniProt Related Accession: | P06732 |
| Molecular Weight: | Calculated: 40kDaObserved: 43kDa |
| NCBI Full Name: | Creatine kinase M-type |
| NCBI Synonym Full Names: | creatine kinase, muscle |
| NCBI Official Symbol: | CKM |
| NCBI Official Synonym Symbols: | CKMM; M-CK |
| NCBI Protein Information: | creatine kinase M-type; creatine kinase M chain |
| UniProt Protein Name: | Creatine kinase M-type |
| UniProt Synonym Protein Names: | Creatine kinase M chain; M-CKCreatine kinase M-type, N-terminally processed |
| Protein Family: | Creatine kinase |
| UniProt Gene Name: | CKM |
| UniProt Entry Name: | KCRM_HUMAN |
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