Human CIB2 Recombinant Protein (RPPB2471)
- SKU:
- RPPB2471
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- CIB2
- Synonyms:
- Calcium and integrin-binding family member 2
- Kinase-interacting protein 2
- KIP 2
- CIB2
- Source:
- Escherichia Coli
- Uniprot:
- O75838
Frequently bought together:
Description
| Product Name: | Human CIB2 Recombinant Protein |
| Product Code: | RPPB2471 |
| Size: | 25µg |
| Species: | Human |
| Target: | CIB2 |
| Synonyms: | Calcium and integrin-binding family member 2, Kinase-interacting protein 2, KIP 2, CIB2, KIP2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CIB2 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 2mM DTT, 100mM NaCl and 1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGNKQTIFTE EQLDNYQDCT FFNKKDILKL HSRFYELAPN LVPMDYRKSP IVHVPMSLII QMPELRENPF KERIVAAFSE DGEGNLTFND FVDMFSVLCE SAPRELKANY AFKIYDFNTD NFICKEDLEL TLARLTKSEL DEEEVVLVCD KVIEEADLDG DGKLGFADFE DMIAKAPDFL STFHIRI |
CIB2 is a member of the calcium and integrin-binding family.CIB2 is possibly a Ca2+-binding regulatory protein which interacts with DNA-dependent protein kinase catalytic subunit (DNA-PKcs). In the skeletal muscle, CIB2 co-localizes with the integrin alpha7B subunit at the sarcolemma and at the neuromuscular and myotendinous junctions. CIB2 is closely related to CIB1.
CIB2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 207 amino acids (1-187a.a.) and having a molecular mass of 23.8kDa (Molecular weight on SDS-PAGE will appear higher). The CIB2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CIB2: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction processProtein type: Calcium-bindingChromosomal Location of Human Ortholog: 15q24Cellular Component: cytoplasm; photoreceptor inner segment; photoreceptor outer segment; stereociliumMolecular Function: calcium ion binding; magnesium ion binding; protein binding; protein homodimerization activityBiological Process: calcium ion homeostasis; elevation of cytosolic calcium ion concentration; photoreceptor cell maintenanceDisease: Deafness, Autosomal Recessive 48; Usher Syndrome, Type Ij |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | O75838 |
| NCBI GenInfo Identifier: | 12230235 |
| NCBI Gene ID: | 10518 |
| NCBI Accession: | O75838.1 |
| UniProt Secondary Accession: | O75838,Q05BT6, B4DDF0, H0YM71 |
| UniProt Related Accession: | O75838 |
| Molecular Weight: | 15,816 Da |
| NCBI Full Name: | Calcium and integrin-binding family member 2 |
| NCBI Synonym Full Names: | calcium and integrin binding family member 2 |
| NCBI Official Symbol: | CIB2 |
| NCBI Official Synonym Symbols: | KIP2; USH1J; DFNB48 |
| NCBI Protein Information: | calcium and integrin-binding family member 2 |
| UniProt Protein Name: | Calcium and integrin-binding family member 2 |
| UniProt Synonym Protein Names: | Kinase-interacting protein 2; KIP 2 |
| Protein Family: | Calcium and integrin-binding family |
| UniProt Gene Name: | CIB2 |
| UniProt Entry Name: | CIB2_HUMAN |
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