Chymotrypsin C (CTRC) is a member of the peptidase S1 family. CTRC is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. CTRC has broad substrate specificity; but prefers tocleave on the carboxyl side of hydrophobic residues. CTRC is expressed primarily in the pancreas; and is secreted into the digestive tract. CTRC plays a protective role in the pancreas by mitigating premature trypsinogen activation through degradation. It has been proposed that CTRC is a key regulator of digestive zymogen activation and is a physiological coactivator of digestive carboxypeptidases proCPA1 and proCPA2. The mutation of CTRC gene encodes the digestive enzyme CTRC contribute to the development of pancreatitis.
Product Name:
Human Chymotrypsin C Recombinant Protein (RPES2814)
Product Code:
RPES2814
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Chymotrypsin-C, Caldecrin, CTRC, CLCR
Accession:
Q99895
Sequence:
Cys17-Leu268
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Chymotrypsin-C is produced by our Mammalian expression system and the target gene encoding Cys17-Leu268 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
29.0 kDa
AP Mol Mass:
35 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 20mM TrisHCl; 150mM NaCl; pH 8.0.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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