Human CHI3L2 Recombinant Protein (RPPB1493)
- SKU:
- RPPB1493
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- CHI3L2
- Synonyms:
- Chitinase 3-Like 2
- Chondrocyte Protein 39
- YKL-39
- YKL39
- Source:
- Sf9 Insect cells
- Uniprot:
- Q15782
Description
| Product Name: | Human CHI3L2 Recombinant Protein |
| Product Code: | RPPB1493 |
| Size: | 10µg |
| Species: | Human |
| Target: | CHI3L2 |
| Synonyms: | Chitinase 3-Like 2, Chondrocyte Protein 39, YKL-39, YKL39,Chitinase-3-Like Protein 2, CHIL2, Chitinase-3-like protein 2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterilefiltered colorless solution. |
| Formulation: | CHI3L2 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | YKLVCYFTNW SQDRQEPGKF TPENIDPFLC SHLIYSFASI ENNKVIIKDKSEVMLYQTIN SLKTKNPKLK ILLSIGGYLF GSKGFHPMVD SSTSRLEFIN SIILFLRNHN FDGLDVSWIYPDQKENTHFT VLIHELAEAF QKDFTKSTKE RLLLTAGVSA GRQMIDNSYQ VEKLAKDLDFINLLSFDFHG SWEKPLITGH NSPLSKGWQD RGPSSYYNVE YAVGYWIHKGMPSEKVVMGI PTYGHSFTLA SAETTVGAPA SGPGAAGPIT ESSGFLAYYE ICQFLKGAKI TRLQDQQVPYAVKGNQWVGY DDVKSMETKV QFLKNLNLGG AMIWSIDMDD FTGKSCNQGP YPLVQAVKRSLGSLLEHHHH HH |
Chitinase 3-Like 2 (CHI3L2) is similar to bacterial chitinases but lacks chitinase activity. CHI3L2 protein is secreted and is involved in cartilage biogenesis. CHI3L2 is a lectin, which binds chitooligosaccharides and other glycans with high affinity, but not heparin.
CHI3L2 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 372 amino acids (27-390a.a.) andhaving a molecular mass of 41.9kDa. (Molecular size on SDS-PAGE will appear atapproximately 40-57kDa).CHI3L2 is expressed with an 8 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CHI3L2: Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: extracellular space Molecular Function:chitin binding; chitinase activity Biological Process: chitin catabolic process |
| NCBI Summary: | The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q15782 |
| NCBI GenInfo Identifier: | 13124005 |
| NCBI Gene ID: | 1117 |
| NCBI Accession: | Q15782.1 |
| UniProt Secondary Accession: | Q15782,Q15749, Q15783, Q5VUV7, Q96F97, A6NNY3, B4DPR7 |
| UniProt Related Accession: | Q15782 |
| Molecular Weight: | 42,508 Da |
| NCBI Full Name: | Chitinase-3-like protein 2 |
| NCBI Synonym Full Names: | chitinase 3 like 2 |
| NCBI Official Symbol: | CHI3L2 |
| NCBI Official Synonym Symbols: | CHIL2; YKL39; YKL-39 |
| NCBI Protein Information: | chitinase-3-like protein 2 |
| UniProt Protein Name: | Chitinase-3-like protein 2 |
| UniProt Synonym Protein Names: | Chondrocyte protein 39; YKL-39 |
| Protein Family: | Chitinase-3-like protein |
| UniProt Gene Name: | CHI3L2 |
| UniProt Entry Name: | CH3L2_HUMAN |
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