Human CECR1 Recombinant Protein (RPPB3142)
- SKU:
- RPPB3142
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- CECR1
- Synonyms:
- Cat Eye Syndrome Chromosome Region
- Candidate 1
- Cat Eye Syndrome Critical Region Protein 1
- IDGFL
- Source:
- Insect Cells
- Uniprot:
- Q9NZK5
Description
| Product Name: | Human CECR1 Recombinant Protein |
| Product Code: | RPPB3142 |
| Size: | 10µg |
| Species: | Human |
| Target: | CECR1 |
| Synonyms: | Cat Eye Syndrome Chromosome Region, Candidate 1, Cat Eye Syndrome Critical Region Protein 1, IDGFL, ADA2, ADGF, Adenosine Deaminase 2, EC 3.5.4.4, SNEDS, PAN, CECR1. |
| Source: | Insect Cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CECR1 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | IDETRAHLLL KEKMMRLGGR LVLNTKEELA NERLMTLKIA EMKEAMRTLI FPPSMHFFQA KHLIERSQVF NILRMMPKGA ALHLHDIGIV TMDWLVRNVT YRPHCHICFT PRGIMQFRFA HPTPRPSEKC SKWILLEDYR KRVQNVTEFD DSLLRNFTLV TQHPEVIYTN QNVVWSKFET IFFTISGLIH YAPVFRDYVF RSMQEFYEDN VLYMEIRARL LPVYELSGEH HDEEWSVKTY QEVAQKFVET HPEFIGIKII YSDHRSKDVA VIAESIRMAM GLRIKFPTVV AGFDLVGHED TGHSLHDYKE ALMIPAKDGV KLPYFFHAGE TDWQGTSIDR NILDALMLNT TRIGHGFALS KHPAVRTYSW KKDIPIEVCP ISNQVLKLVS DLRNHPVATL MATGHPMVIS SDDPAMFGAK GLSYDFYEVF MGIGGMKADL RTLKQLAMNS IKYSTLLESE KNTFMEIWKK RWDKFIADVA TKLEHHHHHH |
Adenosine deaminase CECR1 isoform (CECR1) belongs to a family of adenosine deaminase-related growth factors. Adenosine deaminase is a key enzyme of purine nucleotide metabolism. CECR1 is a secreted protein, which is expressed in various tissues, with the highest expression in the lymphoblasts, heart, lung, and the placenta.
CECR1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 490 amino acids (30-511a.a.) and having a molecular mass of 56.9kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).CECR1 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CECR1: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. Belongs to the adenosine and AMP deaminases family. ADGF subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.5.4.4; Hydrolase; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 22q11.1 Cellular Component: cytosol; extracellular region; extracellular space Molecular Function:adenosine deaminase activity; adenosine receptor binding; growth factor activity; protein homodimerization activity; proteoglycan binding; zinc ion binding Biological Process: adenosine catabolic process; cellular protein metabolic process; hypoxanthine salvage; inosine biosynthetic process Disease: Polyarteritis Nodosa, Childhood-onset; Sneddon Syndrome |
| NCBI Summary: | This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9NZK5 |
| NCBI GenInfo Identifier: | 122065151 |
| NCBI Gene ID: | 51816 |
| NCBI Accession: | Q9NZK5.2 |
| UniProt Secondary Accession: | Q9NZK5,Q6ICF1, Q86UB6, Q8NCJ2, Q96K41, A8K9H4, |
| UniProt Related Accession: | Q9NZK5 |
| Molecular Weight: | 30,668 Da |
| NCBI Full Name: | Adenosine deaminase CECR1 |
| NCBI Synonym Full Names: | cat eye syndrome chromosome region, candidate 1 |
| NCBI Official Symbol: | CECR1 |
| NCBI Official Synonym Symbols: | PAN; ADA2; ADGF; IDGFL; SNEDS |
| NCBI Protein Information: | adenosine deaminase CECR1 |
| UniProt Protein Name: | Adenosine deaminase CECR1 |
| UniProt Synonym Protein Names: | Cat eye syndrome critical region protein 1 |
| Protein Family: | Adenosine deaminase |
| UniProt Gene Name: | CECR1 |
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