Human CEBP Gamma Recombinant Protein (RPPB3141)

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SKU:
RPPB3141
Product type:
Recombinant Protein
Size:
50ug
Species:
Human
Target:
CEBP Gamma
Synonyms:
CCAAT/enhancer-binding protein gamma
Synonyms:
C/EBP gamma
Synonyms:
CEBPG
Synonyms:
GPE1BP
Source:
Escherichia Coli
Uniprot:
P53567
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Description

Product Name:Human CEBP Gamma Recombinant Protein
Product Code:RPPB3141
Size:50µg
Species:Human
Target:CEBP Gamma
Synonyms:CCAAT/enhancer-binding protein gamma, C/EBP gamma, CEBPG, GPE1BP, IG/EBP-1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The protein contains 20mM Tris-HCl pH7.5, 0.1M NaCl and 5mM b-Mercaptoethanol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMPGG GGKAVAPSKQ SKKSSPMDRN SDEYRQRRER NNMAVKKSRL KSKQKAQDTL QRVNQLKEEN ERLEAKIKLL TKELSVLKDL FLEHAHNLAD NVQSISTENT TADGDN

CCAAT/enhancer binding protein(C/EBP) g is a family of transcription factors all contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP family consist of several related proteins, C/EBP a,b,g,d, that form homodimers and/or form heterodimers with each other. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein; a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. C/EBP g may cooperate with Fos to bind PRE- enhancer elements.

CEBP-g Recombinant Human His-Tag fusion protein produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 146 (aa 39-147) and having a molecular mass of 16.5 kDa. The DNA binding domain of CEBP-g was purified by proprietary chromatographic techniques.

UniProt Protein Function:C/EBP-gamma: Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites. Belongs to the bZIP family. C/EBP subfamily.
UniProt Protein Details:

Protein type:DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 19q13.11

Cellular Component: nucleoplasm; nucleus

Molecular Function:DNA binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor binding

Biological Process: B cell differentiation; enucleate erythrocyte differentiation; immune response; liver development; mRNA metabolic process; natural killer cell mediated cytotoxicity; negative regulation of transcription factor activity; positive regulation of DNA binding; positive regulation of DNA repair; positive regulation of interferon-gamma biosynthetic process; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

NCBI Summary:The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Code:P53567
NCBI GenInfo Identifier:1705750
NCBI Gene ID:1054
NCBI Accession:P53567.1
UniProt Secondary Accession:P53567,Q5U052, B2R946,
UniProt Related Accession:P53567
Molecular Weight:16,408 Da
NCBI Full Name:CCAAT/enhancer-binding protein gamma
NCBI Synonym Full Names:CCAAT/enhancer binding protein gamma
NCBI Official Symbol:CEBPG  
NCBI Official Synonym Symbols:GPE1BP; IG/EBP-1  
NCBI Protein Information:CCAAT/enhancer-binding protein gamma
UniProt Protein Name:CCAAT/enhancer-binding protein gamma
Protein Family:CCAAT/enhancer-binding protein
UniProt Gene Name:CEBPG  
UniProt Entry Name:CEBPG_HUMAN
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