Human CEACAM3 Recombinant Protein (RPPB3136)

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SKU:
RPPB3136
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CEACAM3
Synonyms:
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3
Synonyms:
Carcinoembryonic Antigen CGM1
Synonyms:
CD66d Antigen
Synonyms:
CD66D
Source:
Sf9 Insect cells
Uniprot:
P40198
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Description

Product Name:Human CEACAM3 Recombinant Protein
Product Code:RPPB3136
Size:10µg
Species:Human
Target:CEACAM3
Synonyms:Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3, Carcinoembryonic Antigen CGM1, CD66d Antigen , CD66D, CGM1, Carcinoembryonic Antigen Gene Family Member 1, Nonspecific Cross-Reacting Antigen, W264, W282, CEA, CEACAM3.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CEACAM3 protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPKLTIESM PLSVAEGKEV LLLVHNLPQH LFGYSWYKGE RVDGNSLIVG YVIGTQQATP GAAYSGRETI YTNASLLIQN VTQNDIGFYT LQVIKSDLVN EEATGQFHVY QENAPGLPVG AVAGHHHHHH

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3, also known as CEACAM3, is a member of the immunoglobulin super family. The genes in this family encode cell adhesion proteins, which are expressed at higher levels in tumorous tissues rather than in normal tissues. CEACAM3 plays a significant part in the clearance of pathogens through the innate immune system. In addition, CEACAM3 is accountable for RAC1 stimulation in the course of pathogen phagocytosis.

CEACAM3 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 130 amino acids (35-155a.a.) and having a molecular mass of 14.2kDa (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).CEACAM3 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CEACAM3: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation. CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. Belongs to the immunoglobulin superfamily. CEA family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Immunoglobulin superfamily; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: integral to membrane

NCBI Summary:This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
UniProt Code:P40198
NCBI GenInfo Identifier:218511974
NCBI Gene ID:1084
NCBI Accession:P40198.2
UniProt Related Accession:P40198
Molecular Weight:
NCBI Full Name:Carcinoembryonic antigen-related cell adhesion molecule 3
NCBI Synonym Full Names:carcinoembryonic antigen related cell adhesion molecule 3
NCBI Official Symbol:CEACAM3  
NCBI Official Synonym Symbols:CEA; CGM1; W264; W282; CD66D  
NCBI Protein Information:carcinoembryonic antigen-related cell adhesion molecule 3
UniProt Protein Name:Carcinoembryonic antigen-related cell adhesion molecule 3
UniProt Synonym Protein Names:Carcinoembryonic antigen CGM1; CD_antigen: CD66d
UniProt Gene Name:CEACAM3  
UniProt Entry Name:CEAM3_HUMAN
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