Human CDH11 Recombinant Protein (RPPB3130)

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SKU:
RPPB3130
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CDH11
Synonyms:
CAD11
Synonyms:
CDHOB
Synonyms:
OB
Synonyms:
OSF-4
Source:
Escherichia Coli
Uniprot:
P55287
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Description

Product Name:Human CDH11 Recombinant Protein
Product Code:RPPB3130
Size:10µg
Species:Human
Target:CDH11
Synonyms:CAD11, CDHOB, OB, OSF-4, Cadherin 11, Osteoblast cadherin, OB-cadherin.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CDH11 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGWV WNQFFVIEEY TGPDPVLVGR LHSDIDSGDG NIKYILSGEG AGTIFVIDDK SGNIHATKTL DREERAQYTL MAQAVDRDTN RPLEPPSEFI VKVQDINDNP PEFLHETYHA NVPERSNVGT SVIQVTASDA DDPTYGNSAK LVYSILEGQP YFSVEAQTGI IRTALPNMDR EAKEEYHVVI QAKDMGGHMG GLSGTTKVMI TLTDVNDNPP KFPQSVYQMS VSEAAVPGEE VGRVKAKDPD IGENGLVTYN IVDGDGMESF EITTDYETQE GVIKLKKPVD FETKRAYSLK VEAANVHIDP KFISNGPFKD TVTVKIAVED ADEPPMFLAP SYIHEVQENA AAGTVVGRVH AKDPDAANSP IRYSIDRHTD LDRFFTINPE DGFIKTTKPL DREETAWLNI TVFAAEIHNR HQEAKVPVAI RVLDVNDNAP KFAAPYEGFI CESDQTKPLS NQPIVTISAD DKDDTANGPR FIFSLPPEII HNPNFTVRDN RDNTAGVYAR RGGFSRQKQD LYLLPIVISD GGIPPMSSTN TLTIKVCGCD VNGALLSCNA EAYILNAGLS T

Cadherin 11 (CDH11) belongs to the cadherin superfamily (integral membrane proteins) which mediate calcium-dependent cell-cell adhesion. CDH11 is defined based on lacking a HAV cell adhesion recognition sequence specific to type I cadherins. CDH11 protein’s expression in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. CDH11 contributes to the sorting of heterogeneous cell types.

CDH11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 601 amino acids (54-617 a.a) and having a molecular mass of 66.2kDa. CDH11 is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CDH11: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with PCDH8. Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function:calcium ion binding

Biological Process: intercellular junction assembly and maintenance; ossification; corticospinal tract morphogenesis; homophilic cell adhesion; cell adhesion; skeletal development

UniProt Code:P55287
NCBI GenInfo Identifier:16306532
NCBI Gene ID:1009
NCBI Accession:NP_001788
UniProt Secondary Accession:P55287,Q15065, Q15066, Q9UQ93, Q9UQ94, A8K5D6, A8MZC8 B7WP28,
UniProt Related Accession:P55287
Molecular Weight:76,457 Da
NCBI Full Name:cadherin-11 preproprotein
NCBI Synonym Full Names:cadherin 11, type 2, OB-cadherin (osteoblast)
NCBI Official Symbol:CDH11  
NCBI Official Synonym Symbols:OB; CAD11; CDHOB; OSF-4  
NCBI Protein Information:cadherin-11
UniProt Protein Name:Cadherin-11
UniProt Synonym Protein Names:OSF-4; Osteoblast cadherin
Protein Family:Cadherin
UniProt Gene Name:CDH11  
UniProt Entry Name:CAD11_HUMAN
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