Human CDCP1 Recombinant Protein (RPPB3123)

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SKU:
RPPB3123
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
CDCP1
Synonyms:
CUBDomain Containing Protein 1
Synonyms:
Subtractive Immunization M Plus HEp3-Associated135 KDa Protein
Synonyms:
Transmembrane And Associated With Src Kinases
Synonyms:
MembraneGlycoprotein Gp140
Source:
Sf9 Insect cells
Uniprot:
Q9H5V8
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Description

Product Name:Human CDCP1 Recombinant Protein
Product Code:RPPB3123
Size:5µg
Species:Human
Target:CDCP1
Synonyms:CUBDomain Containing Protein 1, Subtractive Immunization M Plus HEp3-Associated135 KDa Protein, Transmembrane And Associated With Src Kinases, MembraneGlycoprotein Gp140, SIMA135, TRASK, CD318 Antigen, CD318, CUB domain-containingprotein 1, Membrane glycoprotein gp140, Subtractive immunization M plusHEp3-associated 135 kDa protein, Transmembrane and associated with src kinases.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CDCP1protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:FEIALPRESNITVLIKLGTP TLLAKPCYIV ISKRHITMLS IKSGERIVFT FSCQSPENHF VIEIQKNIDC MSGPCPFGEV QLQPSTSLLPTLNRTFIWDV KAHKSIGLEL QFSIPRLRQI GPGESCPDGV THSISGRIDA TVVRIGTFCS NGTVSRIKMQEGVKMALHLP WFHPRNVSGF SIANRSSIKR LCIIESVFEG EGSATLMSAN YPEGFPEDEL MTWQFVVPAHLRASVSFLNF NLSNCERKEE RVEYYIPGST TNPEVFKLED KQPGNMAGNF NLSLQGCDQD AQSPGILRLQFQVLVQHPQN ESNKIYVVDL SNERAMSLTI EPRPVKQSRK FVPGCFVCLE SRTCSSNLTL TSGSKHKISFLCDDLTRLWM NVEKTISCTD HRYCQRKSYS LQVPSDILHL PVELHDFSWK LLVPKDRLSL VLVPAQKLQQHTHEKPCNTS FSYLVASAIP SQDLYFGSFC PGGSIKQIQV KQNISVTLRT FAPSFQQEAS RQGLTVSFIPYFKEEGVFTV TPDTKSKVYL RTPNWDRGLP SLTSVSWNIS VPRDQVACLT FFKERSGVVC QTGRAFMIIQEQRTRAEEIF SLDEDVLPKP SFHHHSFWVN ISNCSPTSGK QLDLLFSVTL TPRTVDLTLE HHHHHH

CUB Domain Containing Protein 1, also known as CDCP1 is a transmembraneprotein which contains three extracellular CUB domains. CDCP1 is implicated incell adhesion and cell matrix association. In addition, CDCP1 takes part in theregulation of anchorage versus migration or proliferation versusdifferentiation through its phosphorylation. CDCP1 is also a novel marker for leukemiadiagnosis as well as for immature hematopoietic stem cell subsets. Furthermore,the extracellular region of human CDCP1 shares amino acid identity sequencewith the mouse CDCP1.

CDCP1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 646 amino acids (30-667a.a.) and having a molecular mass of 72.8kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). CDCP1 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CDCP1: a transmembrane protein containing three extracellular CUB domains involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation depending upon its phosphorylation status. Interacts with N- and P-cadherin, syndecans 1 and 4, the serine protease ST14, SRC and PKCG. Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Its expression level is correlated with the metastatic ability of carcinoma cells. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. Three alternatively spliced human isoforms have been reported. Isoform 1 is a single-pass membrane protein that may also be shed, giving rise to a soluble peptide. Isoform 3 is secreted.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.31

Molecular Function:protein binding

NCBI Summary:This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
UniProt Code:Q9H5V8
NCBI GenInfo Identifier:317373455
NCBI Gene ID:64866
NCBI Accession:Q9H5V8.3
UniProt Secondary Accession:Q9H5V8,Q49UB4, Q6NT71, Q6U9Y2, Q8WU91, Q96QU7, Q9H676 Q9H8C2,
UniProt Related Accession:Q9H5V8
Molecular Weight:37,818 Da
NCBI Full Name:CUB domain-containing protein 1
NCBI Synonym Full Names:CUB domain containing protein 1
NCBI Official Symbol:CDCP1  
NCBI Official Synonym Symbols:CD318; TRASK; SIMA135  
NCBI Protein Information:CUB domain-containing protein 1
UniProt Protein Name:CUB domain-containing protein 1
UniProt Synonym Protein Names:Membrane glycoprotein gp140; Subtractive immunization M plus HEp3-associated 135 kDa protein; SIMA135; Transmembrane and associated with src kinases; CD_antigen: CD318
Protein Family:CUB domain-containing protein
UniProt Gene Name:CDCP1  
UniProt Entry Name:CDCP1_HUMAN
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