Human CDCP1/CD318 Recombinant Protein (RPES1511)

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SKU:
RPES1511
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Description

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Human CDCP1/CD318 Recombinant Protein

CUB domain-containing protein 1(CDCP1) is a transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains; and a smaller intracellular domain (ICD) containing five tyrosines. CDCP1 is widely expressed in human epithelial tissues; but its phosphorylation is only seen in mitotically detached or shedding cells; consistent with its role in the negative regulation of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsinor EDTA; or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype.

Product Name:Human CDCP1/CD318 Recombinant Protein (RPES1511)
Product Code:RPES1511
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:CUB domain-containing protein 1,Membrane glycoprotein gp140,Subtractive immunization M plus HEp3-associated 135 kDa protein,SIMA135,Transmembrane and associated with src kinases,CD318,TRASK
Accession:Q9H5V8-3
Sequence:Phe30-Ser341
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human CUB domain-containing protein 1 is produced by our Mammalian expression system and the target gene encoding Phe30-Ser341 is expressed with a 6His tag at the C-terminus.
Purity:> 90 % as determined by reducing SDS-PAGE.
Mol Mass:36.1 kDa
AP Mol Mass:55 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB;150mM NaCl;pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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