PE/Cyanine5 Anti-Human CD8a Antibody [OKT-8] (AGEL0411)

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SKU:
AGEL0411
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
OKT-8
Conjugation:
PE/Cy5
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine5 Anti-Human CD8a Antibody [OKT-8]

The Human CD8a Monoclonal Antibody (PE/Cy5 Conjugated) is a cutting-edge tool designed for precise detection and analysis of CD8a, a critical cell surface marker involved in immune responses. This antibody, known as OKT-8, is meticulously engineered for exceptional specificity and sensitivity in identifying CD8a in human samples. With its PE/Cy5 conjugation, this antibody offers enhanced detection capabilities for flow cytometry applications, enabling accurate profiling of CD8a-expressing cells in research settings.CD8a, a core component of cytotoxic T cells, plays a pivotal role in immune surveillance and immune response regulation. Its expression level and functionality are key indicators of immune health and function, making it a key target for immunological studies and disease research. By precisely targeting CD8a, researchers can explore its involvement in various immune processes, including antigen recognition, immune activation, and immune regulation, ultimately advancing our understanding of immune system function and dysfunction in conditions such as infections, autoimmune diseases, and cancer.

The Human CD8a Monoclonal Antibody (PE/Cy5 Conjugated) OKT-8 is a valuable asset for researchers delving into immunology, oncology, and infectious diseases. Its high specificity, reliability, and compatibility with flow cytometry techniques make it an indispensable tool for dissecting the role of CD8a in immune responses and disease pathology. Explore the intricate world of CD8a with confidence and precision using this innovative antibody, paving the way for groundbreaking discoveries in the field of immunological research.

Product Title:PE/Cyanine5 Anti-Human CD8a Antibody [OKT-8]
SKU:AGEL0411
Size:20 Tests, 100 Tests, 200 Tests
Clone No:OKT-8
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE/Cyanine5 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P01732
Gene ID:925
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

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