Biotin Anti-Human CD8a Antibody [OKT-8] (AGEL0406)

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SKU:
AGEL0406
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
OKT-8
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Human CD8a Antibody [OKT-8]

The Human CD8a Monoclonal Antibody (Biotin Conjugated) - OKT-8 (AGEL0406) offered by AssayGenie is a cutting-edge tool for researchers delving into the intricacies of the CD8a cell surface marker. CD8a is a crucial component of the immune system, primarily found on cytotoxic T cells and involved in recognizing antigens presented by major histocompatibility complex (MHC) class I molecules. This monoclonal antibody, conjugated with biotin for enhanced detection capabilities, provides exceptional specificity and sensitivity in identifying CD8a in human samples.The OKT-8 antibody is meticulously developed to target the CD8a protein, facilitating precise detection and analysis in a variety of cell types. Its reliability and performance have been validated for use in techniques such as flow cytometry and immunohistochemistry, making it an indispensable tool for immunologists, oncologists, and researchers exploring immune responses and cell-mediated cytotoxicity.

By utilizing the OKT-8 antibody, scientists can deepen their understanding of CD8a's role in immune surveillance, vaccination responses, and autoimmune diseases. Furthermore, its application extends to investigating CD8a expression patterns in cancer cells, aiding in the development of targeted therapies and immunotherapies. Trust in the Human CD8a Monoclonal Antibody (Biotin Conjugated) - OKT-8 (AGEL0406) to support your research endeavors and unlock valuable insights into the complexities of cellular immunity and disease pathology.

Product Title:Biotin Anti-Human CD8a Antibody [OKT-8]
SKU:AGEL0406
Size:25µg, 100µg
Clone No:OKT-8
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Biotin Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P01732
Gene ID:925
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

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